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J Breath Res

Title:		Day-long reduction of oral malodor by a palatal mucoadhesive tablet containing herbal formulation
Author(s):		Sterer N; Ovadia O; Weiss EI; Perez Davidi M;
Address:		"Department of Prosthodontics, Goldschleger School of Dental Medicine, Tel-Aviv University, Ramat-Aviv 69978, Israel. drsterer@gmail.com"
Journal Title:		J Breath Res
Year:		2013
Volume:		20130322
Issue:		2
Page Number:		26004 -
DOI:		10.1088/1752-7155/7/2/026004
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"Previous research has shown the oral malodor reducing abilities of an herbal formulation delivered using a palatal mucoadhesive tablet. The aim of the present study was to test the day-long effect of this preventive treatment on oral malodor reduction as compared with placebo and commercial mouthwash. Forty young healthy subjects (mean age, 25.8 +/- 1.8 yrs, 19 females) presenting with oral malodor were randomly assigned to use one of the three tested products: herbal mucoadhesive tablets, placebo mucoadhesive tablets and a commercial mouthwash. Following baseline measurements, subjects were instructed to use the products in the evening of the same day and the following morning. Baseline and follow-up measurements were conducted in the afternoon and included odor judge scores (two judges), volatile sulfide compounds (VSC) levels using a sulfide monitor (Halimeter) and saliva sample for beta-galactosidase activity assay. The herbal mucoadhesive tablet caused a significant reduction in malodor scores (p = 0.004), VSC levels (p = 0.002) and beta-galactosidase assay (p = 0.02) as compared to the placebo, and reduced malodor level to below the clinical threshold (mean odor judge score of 1.7). These results demonstrate the efficacy of the herbal formulation delivered using a mucoadhesive tablet for day-long prevention of oral malodor"
Keywords:		"Administration, Oral Adult Breath Tests/*methods Exhalation Female Follow-Up Studies Halitosis/metabolism/*prevention & control Humans Male Palate, Soft Phytotherapy Plant Extracts/*administration & dosage *Plants, Medicinal Saliva/*chemistry Tablets Time;"
Notes:		"MedlineSterer, N Ovadia, O Weiss, E I Perez Davidi, M eng Randomized Controlled Trial England 2013/03/23 J Breath Res. 2013 Jun; 7(2):026004. doi: 10.1088/1752-7155/7/2/026004. Epub 2013 Mar 22"