| Title: | Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis |
| Author(s): | Smith D; Sovova K; Dryahina K; Dousova T; Drevinek P; Spanel P; |
| Address: | "Institute for Science and Technology in Medicine, Medical School, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, UK" |
| DOI: | 10.1088/1752-7155/10/2/021002 |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "A study has been carried out of the volatile organic compounds present in the exhaled breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid vapour concentration measured by selected ion flow tube mass spectrometry (SIFT-MS) is significantly elevated in the exhaled breath of CF patients, independent of the Pseudomonas aeruginosa (PA) infection status (PA-infected median 170 ppbv; PA-negative median 182 ppbv), compared to that of healthy controls (median 48 ppbv). The cause for this may be decreased pH of the mucus lining the CF airways. Thus, we speculate that non-invasive measurement of breath acetic acid concentration could serve as an indicator of the acidity of the CF airways mucosa" |
| Keywords: | "Acetic Acid/*analysis Adolescent Adult Biomarkers/analysis Breath Tests/*methods Child Child, Preschool Cystic Fibrosis/complications/*physiopathology Exhalation Female Humans Male Mass Spectrometry Pseudomonas Infections/complications/physiopathology Pse;" |
| Notes: | "MedlineSmith, David Sovova, Kristyna Dryahina, Kseniya Dousova, Tereza Drevinek, Pavel Spanel, Patrik eng Research Support, Non-U.S. Gov't England 2016/05/18 J Breath Res. 2016 May 17; 10(2):021002. doi: 10.1088/1752-7155/10/2/021002" |
