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J Sci Food Agric

Title:		Application of response surface methodology to optimise supercritical carbon dioxide extraction of volatile compounds from Crocus sativus
Author(s):		Shao Q; Huang Y; Zhou A; Guo H; Zhang A; Wang Y;
Address:
Journal Title:		J Sci Food Agric
Year:		2014
Volume:		94
Issue:		7
Page Number:		1430 - 1436
DOI:		10.1002/jsfa.6435
ISSN/ISBN:		1097-0010 (Electronic) 0022-5142 (Linking)
Abstract:		"BACKGROUND: Crocus sativus has been used as a traditional Chinese medicine for a long time. The volatile compounds of C. sativus appear biologically active and may act as antioxidants as well as anticonvulsants, antidepressants and antitumour agents. In order to obtain the highest possible yield of essential oils from C. sativus, response surface methodology was employed to optimise the conditions of supercritical fluid carbon dioxide extraction of the volatile compounds from C. sativus. Four factorswere investigated: temperature, pressure, extraction time and carbon dioxide flow rate. Furthermore, the chemical compositions of the volatile compounds extracted by supercritical fluid extraction were compared with those obtained by hydro-distillation and Soxhlet extraction. RESULTS: The optimum extraction conditions were found to be: optimised temperature 44.9 degrees C, pressure 34.9 MPa, extraction time 150.2 min and CO(2) flow rate 10.1 L h(-)(1). Under these conditions, the mean extraction yield was 10.94 g kg(-)(1). The volatile compounds extracted by supercritical fluid extraction and Soxhlet extraction contained a large amount of unsaturated fatty acids. CONCLUSION: Response surface methodology was successfully applied for supercritical fluid CO(2) extraction optimisation of the volatile compounds from C. sativus. The study showed that pressure and CO(2) flow rate had significant effect on volatile compounds yield produced by supercritical fluid extraction. This study is beneficial for the further research operating on a large scale"
Keywords:		"Anticonvulsants/analysis/chemistry/isolation & purification Antidepressive Agents/analysis/chemistry/isolation & purification Antineoplastic Agents, Phytogenic/analysis/chemistry/isolation & purification Antioxidants/*analysis/chemistry/isolation & purifi;"
Notes:		"MedlineShao, Qingsong Huang, Yuqiu Zhou, Aicun Guo, Haipeng Zhang, Ailian Wang, Yong eng Comparative Study Evaluation Study Research Support, Non-U.S. Gov't England 2014/05/17 J Sci Food Agric. 2014 May; 94(7):1430-6. doi: 10.1002/jsfa.6435"