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J Breath Res

Title:		Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE)
Author(s):		Shahrokny P; Maison N; Riemann L; Ehrmann M; DeLuca D; Schuchardt S; Thiele D; Weckmann M; Dittrich AM; Schaub B; Brinkmann F; Hansen G; Kopp M; von Mutius E; Rabe K; Bahmer T; Hohlfeld J; Grychtol R; Holz O;
Address:		"Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Feodor-Lynen-Str. 15, Hannover, 30625, GERMANY. Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, German Center for Lung Research (CPC-M, DZL), Lindwurmstrasse 4, Munich, 80337, GERMANY. Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, German Center for Lung Research (BREATH, DZL), Carl-Neuberg-Strasse 1, Hannover, 30625, GERMANY. Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, German Center for Lung Research (CPC-M, DZL), Lindwurmstr 4, Munich, 80337, GERMANY. Hannover Medical School, German Center for Lung Research (BREATH, DZL), Carl-Neuberg-Strasse 1, Hannover, 30625, GERMANY. Bio- and Environmental Analytics, Fraunhofer-Institut fur Toxikologie und Experimentelle Medizin, Feodor-Lynen-Str. 15, Hannover, Hannover, Niedersachsen, 30625, GERMANY. Division of Pediatric Pulmonology and Allergology, University Children's Hospital, German Center for Lung Research (ARCN, DZL), Ratzeburger Allee 160, Lubeck, 23538, GERMANY. Department of Paediatrics, Inselspital University Hospital Bern, Freiburgstr 18, Bern, Bern, 3010, SWITZERLAND. LungenClinic Grosshansdorf and Department of Medicine, Christian-Albrechts-University Kiel, German Center for Lung Research (ARCN, DZL), Wohrendamm 80, Grosshansdorf, 22927, GERMANY. ITEM, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Str. 1, Hannover, 30625, GERMANY. Clinical Airway Research, Fraunhofer ITEM, Department of Clinical Airway Research, German Center for Lung Research (BREATH, DZL), Feodor-Lynen-Str. 15, Hannover, 30625, GERMANY"
Journal Title:		J Breath Res
Year:		2023
Volume:		20230821
Issue:
Page Number:		-
DOI:		10.1088/1752-7163/acf23e
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"Background Exhaled breath contains numerous volatile organic compounds (VOCs) known to be related to lung disease like asthma. Its collection is non-invasive, simple to perform and therefore an attractive method for the use even in young children. We analysed breath in children of the multicenter All Age Asthma Cohort (ALLIANCE) to evaluate if 'breathomics' have the potential to phenotype patients with asthma and wheeze, and to identify extrinsic risk factors for underlying disease mechanisms. Methods A breath sample was collected from 142 children (asthma: 51, pre-school wheezers: 55, healthy controls: 36) and analysed using gas chromatography-mass spectrometry (GC/MS). Children were diagnosed according to GINA guidelines and comprehensively examined each year over up to seven years. Forty children repeated the breath collection after 24 or 48 months. Results Most breath VOCs differing between groups reflect the exposome of the children. We observed lower levels of lifestyle-related VOCs and higher levels of the environmental pollutants, especially naphthalene, in children with asthma or wheeze. Naphthalene was also higher in symptomatic patients and in wheezers with recent inhaled corticosteroid use. No relationships with lung function or TH2 inflammation were detected. Conclusion Increased levels of naphthalene in asthmatics and wheezers and the relationship to disease severity could indicate a role of environmental or indoor air pollution for the development or progress of asthma. Breath VOCs might help to elucidate the role of the exposome for the development of asthma. The study was registered at ClinicalTrials.gov (NCT02496468). "
Keywords:		Alliance Voc exhaled breath pediatric asthma wheeze;
Notes:		"PublisherShahrokny, Pedram Maison, Nicole Riemann, Lennart Ehrmann, Maximilian DeLuca, David Schuchardt, Sven Thiele, Dominik Weckmann, Markus Dittrich, Anna-Maria Schaub, Bianca Brinkmann, Folke Hansen, Gesine Kopp, Matthias von Mutius, Erika Rabe, Klaus Bahmer, Thomas Hohlfeld, Jens Grychtol, Ruth Holz, Olaf eng England 2023/08/22 J Breath Res. 2023 Aug 21. doi: 10.1088/1752-7163/acf23e"