| Title: | Increased dopamine after mating impairs olfaction and prevents odor interference with pregnancy |
| Author(s): | Serguera C; Triaca V; Kelly-Barrett J; Banchaabouchi MA; Minichiello L; |
| Address: | "European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, 00015 Monterotondo, Italy" |
| ISSN/ISBN: | 1546-1726 (Electronic) 1097-6256 (Linking) |
| Abstract: | "In rodents, social odor sensing influences female reproductive status by affecting neuroendocrine cascades. The odor of male mouse urine can induce ovulation or block pregnancy within 3 d post coitus. Females avoid the action of such olfactory stimuli after embryonic implantation. The mechanisms underlying these changes are unknown. Here we report that shortly after mating, a surge in dopamine in the mouse main olfactory bulb impairs the perception of social odors contained in male urine. Treatment of females at 6.5 d post coitus with a dopamine D2 receptor antagonist restores social odor sensing and favors disruption of pregnancy by inhibition of prolactin release, when administered in the presence of alien male urine odors. These results show that an active sensory barrier blocks social olfactory cues detrimental to pregnancy, consistent with the main olfactory bulb being a major relay through which social odor modulates reproductive status" |
| Keywords: | "Animals Cues Dopamine/*metabolism Dopamine Antagonists/pharmacology Dopamine D2 Receptor Antagonists Embryo Implantation/drug effects/physiology Female Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neurons/drug effects/metabolism *Odorants Olfactory Bu;" |
| Notes: | "MedlineSerguera, Che Triaca, Viviana Kelly-Barrett, Jakki Banchaabouchi, Mumna Al Minichiello, Liliana eng Research Support, Non-U.S. Gov't 2008/07/22 Nat Neurosci. 2008 Aug; 11(8):949-56. doi: 10.1038/nn.2154. Epub 2008 Jul 20" |
