| Title: | A mobile instrumentation platform to distinguish airway disorders |
| Author(s): | Schivo M; Seichter F; Aksenov AA; Pasamontes A; Peirano DJ; Mizaikoff B; Kenyon NJ; Davis CE; |
| Address: | "Division of Pulmonary, Critical Care, and Sleep Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA" |
| DOI: | 10.1088/1752-7155/7/1/017113 |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Print) 1752-7155 (Linking) |
| Abstract: | "Asthma and chronic obstructive pulmonary disease (COPD) are distinct but clinically overlapping airway disorders which often create diagnostic and therapeutic dilemmas. Current strategies to discriminate these diseases are limited by insensitivity and poor performance due to biologic variability. We tested the hypothesis that a gas chromatograph/differential mobility spectrometer (GC/DMS) sensor could distinguish between clinically well-defined groups with airway disorders based on the volatile organic compounds (VOCs) obtained from exhaled breath. After comparing VOC profiles obtained from 13 asthma, 5 COPD and 13 healthy control subjects, we found that VOC profiles distinguished asthma from healthy controls and also a subgroup of asthmatics taking the drug omalizumab from healthy controls. The VOC profiles could not distinguish between COPD and any of the other groups. Our results show a potential application of the GC/DMS for non-invasive and bedside diagnostics of asthma and asthma therapy monitoring. Future studies will focus on larger sample sizes and patient cohorts" |
| Keywords: | "Adult Aged Anti-Asthmatic Agents/therapeutic use Antibodies, Anti-Idiotypic/therapeutic use Antibodies, Monoclonal, Humanized/therapeutic use Asthma/drug therapy/*metabolism Breath Tests/*instrumentation Case-Control Studies Chromatography, Gas/instrument;" |
| Notes: | "MedlineSchivo, Michael Seichter, Felicia Aksenov, Alexander A Pasamontes, Alberto Peirano, Daniel J Mizaikoff, Boris Kenyon, Nicholas J Davis, Cristina E eng R01 HL105573/HL/NHLBI NIH HHS/ T32 ES007059/ES/NIEHS NIH HHS/ HL 105573/HL/NHLBI NIH HHS/ K12 8KL2TR000134-07/TR/NCATS NIH HHS/ UL1 RR024146/RR/NCRR NIH HHS/ UL1 TR000002/TR/NCATS NIH HHS/ T32-ES007059/ES/NIEHS NIH HHS/ T32-HL007013/HL/NHLBI NIH HHS/ T32 HL007013/HL/NHLBI NIH HHS/ KL2 TR000134/TR/NCATS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2013/03/01 J Breath Res. 2013 Mar; 7(1):017113. doi: 10.1088/1752-7155/7/1/017113. Epub 2013 Feb 27" |
