| Title: | Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose |
| Author(s): | Scheepers M; Al-Difaie ZJJ; Wintjens A; Engelen SME; Havekes B; Lubbers T; Coolsen MME; van der Palen J; van Ginhoven TM; Vriens M; Bouvy ND; |
| Address: | "GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center, Maastricht, The Netherlands. Section Cognition, Data and Education, University of Twente, Enschede, The Netherlands. Department of Epidemiology, Medisch Spectrum Twente, Enschede, The Netherlands. Department of Surgery, Erasmus University, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Surgery, Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "This proof-of-principle study investigates the diagnostic performance of the Aeonose in differentiating malignant from benign thyroid diseases based on volatile organic compound analysis in exhaled breath. All patients with a suspicious thyroid nodule planned for surgery, exhaled in the Aeonose. Definitive diagnosis was provided by histopathological determination after surgical resection. Breath samples were analyzed utilizing artificial neural networking. About 133 participants were included, 48 of whom were diagnosed with well-differentiated thyroid cancer. A sensitivity of 0.73 and a negative predictive value (NPV) of 0.82 were found. The sensitivity and NPV improved to 0.94 and 0.95 respectively after adding clinical variables via multivariate logistic regression analysis. This study demonstrates the feasibility of the Aeonose to discriminate between malignant and benign thyroid disease. With a high NPV, low cost, and non-invasive nature, the Aeonose may be a promising diagnostic tool in the detection of thyroid cancer" |
| Keywords: | Breath Tests Electronic Nose Exhalation Humans *Thyroid Neoplasms/diagnosis *Volatile Organic Compounds/analysis exhaled air innovative diagnostics thyroid carcinoma volatile organic compounds; |
| Notes: | "MedlineScheepers, Max H M C Al-Difaie, Zaid J J Wintjens, Anne G W E Engelen, Sanne M E Havekes, Bas Lubbers, Tim Coolsen, Marielle M E van der Palen, Job van Ginhoven, Tessa M Vriens, Menno Bouvy, Nicole D eng England 2022/06/11 J Breath Res. 2022 Jun 21; 16(3). doi: 10.1088/1752-7163/ac77a9" |
