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Environ Sci Pollut Res Int

Title:		"Haemato-biochemical, mutagenic, and histopathological changes in Oreochromis niloticus exposed to BTX"
Author(s):		Sayed AEH; Idriss SK; Abdel-Ghaffar SK; Hussein AAA;
Address:		"Molecular Biology Researches & Studies Institute, Assiut University, 71516, Assiut, Egypt. alaasayed@aun.edu.eg. Zoology Department, Faculty of Science, Assiut University, 71516, Assiut, Egypt. alaasayed@aun.edu.eg. Department of Fish Disease and Management, Faculty of Veterinary of Medicine, Assiut University, 71516, Assiut, Egypt. Molecular Biology Researches & Studies Institute, Assiut University, 71516, Assiut, Egypt"
Journal Title:		Environ Sci Pollut Res Int
Year:		2023
Volume:		20230401
Issue:		21
Page Number:		59301 - 59315
DOI:		10.1007/s11356-023-26604-2
ISSN/ISBN:		1614-7499 (Electronic) 0944-1344 (Print) 0944-1344 (Linking)
Abstract:		"The study of the DNA damage response in erythrocytes after exposure to volatile organic compounds (VOCs) can present evidence for its potential effect as genotoxic- biomarkers for environmental pollution. Although VOCs are dangerous pollutants, still little is known about hemotoxic, cytotoxic, and genotoxic effects of such pollutants on fish. We optimized an assay method for apoptosis and DNA damage in erythrocytes of adult tilapia fish after 15 days exposure to benzene (0.762 ng/L), toluene (26.614 ng/L), and xylene (89.403 ng/L). The highest level of apoptosis and DNA damage were recorded in benzene-exposed fish, as was the highest level of histopathological alterations in gills, liver, and kidney. The imbalance of the antioxidants profile explained the stress-case reported in exposed fish. These results suggest that hemotoxic, cytotoxic, genotoxic, and tissue damage were recorded after exposure to BTX in Oreochromis niloticus"
Keywords:		"Animals *Cichlids/genetics Mutagens/pharmacology Benzene Antioxidants/pharmacology *Environmental Pollutants/pharmacology *Water Pollutants, Chemical/toxicity Liver Gills Acridine orange Btx DNA damage Erythrocytes Fish;"
Notes:		"MedlineSayed, Alaa El-Din H Idriss, Shaimaa K Abdel-Ghaffar, Sary Kh Hussein, Asmaa A A eng Germany 2023/04/03 Environ Sci Pollut Res Int. 2023 May; 30(21):59301-59315. doi: 10.1007/s11356-023-26604-2. Epub 2023 Apr 1"