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Nat Commun

Title:		Human-relevant levels of added sugar consumption increase female mortality and lower male fitness in mice
Author(s):		Ruff JS; Suchy AK; Hugentobler SA; Sosa MM; Schwartz BL; Morrison LC; Gieng SH; Shigenaga MK; Potts WK;
Address:		"Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA. j.ruff@utah.edu"
Journal Title:		Nat Commun
Year:		2013
Volume:		4
Issue:
Page Number:		2245 -
DOI:		10.1038/ncomms3245
ISSN/ISBN:		2041-1723 (Electronic) 2041-1723 (Linking)
Abstract:		"Consumption of added sugar has increased over recent decades and is correlated with numerous diseases. Rodent models have elucidated mechanisms of toxicity, but only at concentrations beyond typical human exposure. Here we show that comparatively low levels of added sugar consumption have substantial negative effects on mouse survival, competitive ability, and reproduction. Using Organismal Performance Assays--in which mice fed human-relevant concentrations of added sugar (25% kcal from a mixture of fructose and glucose, modeling high fructose corn syrup) and control mice compete in seminatural enclosures for territories, resources and mates--we demonstrate that fructose/glucose-fed females experience a twofold increase in mortality while fructose/glucose-fed males control 26% fewer territories and produce 25% less offspring. These findings represent the lowest level of sugar consumption shown to adversely affect mammalian health. Clinical defects of fructose/glucose-fed mice were decreased glucose clearance and increased fasting cholesterol. Our data highlight that physiological adversity can exist when clinical disruptions are minor, and suggest that Organismal Performance Assays represent a promising technique for unmasking negative effects of toxicants"
Keywords:		"Animals Animals, Wild Blood Glucose/physiology Body Weight/drug effects Cholesterol/blood Competitive Behavior/*drug effects/physiology Eating Energy Intake/drug effects/physiology Female Fructose/*adverse effects/blood/metabolism Glucose/*adverse effects;"
Notes:		"MedlineRuff, James S Suchy, Amanda K Hugentobler, Sara A Sosa, Mirtha M Schwartz, Bradley L Morrison, Linda C Gieng, Sin H Shigenaga, Mark K Potts, Wayne K eng R01 GM039578/GM/NIGMS NIH HHS/ R01-GM039578/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. England 2013/08/15 Nat Commun. 2013; 4:2245. doi: 10.1038/ncomms3245"