| Title: | Control of C. elegans larval development by neuronal expression of a TGF-beta homolog |
| Author(s): | Ren P; Lim CS; Johnsen R; Albert PS; Pilgrim D; Riddle DL; |
| Address: | "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, Columbia, MO 65211, USA. riddle@biosci.mbp.missouri.edu" |
| DOI: | 10.1126/science.274.5291.1389 |
| ISSN/ISBN: | 0036-8075 (Print) 0036-8075 (Linking) |
| Abstract: | "The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made" |
| Keywords: | "Amino Acid Sequence Animals Animals, Genetically Modified Caenorhabditis elegans/genetics/*growth & development/metabolism *Caenorhabditis elegans Proteins Genes, Helminth Genes, Reporter Green Fluorescent Proteins Helminth Proteins/chemistry/genetics/*ph;" |
| Notes: | "MedlineRen, P Lim, C S Johnsen, R Albert, P S Pilgrim, D Riddle, D L eng HD11239/HD/NICHD NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1996/11/22 Science. 1996 Nov 22; 274(5291):1389-91. doi: 10.1126/science.274.5291.1389" |
