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Anal Chim Acta

Title:		An economical setup for atmospheric pressure chemical ionization drift tube ion-mobility mass spectrometry
Author(s):		Raju CM; Buchowiecki K; Urban PL;
Address:		"Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu, 300044, Taiwan. Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu, 300044, Taiwan; Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu, 300044, Taiwan. Electronic address: urban@mx.nthu.edu.tw"
Journal Title:		Anal Chim Acta
Year:		2023
Volume:		20230517
Issue:
Page Number:		341359 -
DOI:		10.1016/j.aca.2023.341359
ISSN/ISBN:		1873-4324 (Electronic) 0003-2670 (Linking)
Abstract:		"Ion-mobility (IM) separations-performed in conjunction with mass spectrometry (MS)-increase selectivity of MS analyses. However, IM-MS instruments are costly, and many laboratories are only equipped with standard MS instruments without an IM separation stage. Therefore, it is appealing to upgrade the existing mass spectrometers with low-cost IM separation devices. Such devices can be constructed using widely available materials such as printed-circuit boards (PCBs). We demonstrate coupling of an economical PCB-based IM spectrometer (disclosed previously) with a commercial triple quadrupole (QQQ) mass spectrometer. The presented PCB-IM-QQQ-MS system incorporates an atmospheric pressure chemical ionization (APCI) source, drift tube comprising desolvation and drift regions, ion gates, and transfer line to the mass spectrometer. The ion gating is accomplished with the aid of two floated pulsers. The separated ions are divided into packets, which are sequentially introduced to the mass spectrometer. Volatile organic compounds (VOCs) are transferred with the aid of nitrogen gas flow from the sample chamber to the APCI source. The operation of the system has been demonstrated using standard compounds. The limits of detection for 2,4-lutidine, (-)-nicotine, and pyridine are 2.02 x 10(-7) M, 1.54 x 10(-9) mol, and 4.79 x 10(-10) mol, respectively. The system was also used to monitor VOCs emitted from the porcine skin after exposure to nicotine patches, and VOCs released from meat undergoing the spoilage process. We believe this simple APCI-PCB-IM-QQQ-MS platform can be reproduced by others to augment the capabilities of the existing MS instrumentation"
Keywords:		Hyphenated technique Ion-mobility spectroscopy Low-cost instrument Mass spectrometry Volatile organic compound;
Notes:		"PubMed-not-MEDLINERaju, Chamarthi Maheswar Buchowiecki, Krzysztof Urban, Pawel L eng Netherlands 2023/06/03 Anal Chim Acta. 2023 Aug 8; 1268:341359. doi: 10.1016/j.aca.2023.341359. Epub 2023 May 17"