| Title: | Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice |
| Author(s): | Rahman MS; Pang WK; Ryu DY; Park YJ; Ryu BY; Pang MG; |
| Address: | "Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do 17546, Republic of Korea. Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do 17546, Republic of Korea. Electronic address: mgpang@cau.ac.kr" |
| DOI: | 10.1016/j.jhazmat.2021.125791 |
| ISSN/ISBN: | 1873-3336 (Electronic) 0304-3894 (Linking) |
| Abstract: | "Growing evidence suggests that developmental exposure to bisphenol A (BPA)-a synthetic endocrine disruptor-causes atypical reproductive phenotypes that may persist for generations. However, the precise mechanism(s) by which BPA causes these adverse consequences is unclear. Here, pregnant female mice were orally exposed to 50 mug, 5 mg, and 50 mg BPA/kg body weight (bw)/day from 7 to 14 days of gestation. Corn oil treatments were used as control. The first filial generation (F1) and F2 males were used to generate F3 by mating them with unexposed females. High BPA doses impaired F1 and/or F1-F2 (multigenerational effect) male reproduction (i.e., disrupted testicular germ cell organization and spermatogenesis, altered sperm biochemical properties, and decreased sperm count, motility, and fertility) but not that of F3 males (transgenerational effect). Moreover, the observed multigenerational transmission of the abnormal reproductive traits was associated with alterations in the sperm DNA methylation patterns of specific male generations, with substantial proteomic changes in F1-F3 at the highest BPA dose. Given that the proteins related to male fertility and epigenetic modification are highly conserved among vertebrates, our findings may shed light on how exposure to environmental factors during pregnancy affects fertility in future generations in both humans and the other animals" |
| Keywords: | Animals Benzhydryl Compounds/toxicity *Endocrine Disruptors/toxicity Female Fertility Male Mice Phenols Pregnancy *Prenatal Exposure Delayed Effects/chemically induced Proteomics Spermatozoa Bisphenol A Gestation Male reproduction Multigeneration Transgen; |
| Notes: | "MedlineRahman, Md Saidur Pang, Won-Ki Ryu, Do-Yeal Park, Yoo-Jin Ryu, Buom-Yong Pang, Myung-Geol eng Research Support, Non-U.S. Gov't Netherlands 2021/04/12 J Hazard Mater. 2021 Aug 15; 416:125791. doi: 10.1016/j.jhazmat.2021.125791. Epub 2021 Apr 1" |
