| Title: | Moth pheromone binding proteins contribute to the excitation of olfactory receptor cells |
| Address: | "Max-Planck-Institut fur Verhaltensphysiologie Seewiesen, 82319 Starnberg, Germany. pophof@mpi-seewiesen.mpg.de" |
| DOI: | 10.1007/s00114-002-0364-5 |
| ISSN/ISBN: | 0028-1042 (Print) 0028-1042 (Linking) |
| Abstract: | "Pheromone binding proteins (PBPs) occur in high concentrations in the sensillum lymph surrounding the sensory dendrites of moth pheromone-sensitive sensilla. They were shown to transport the lipophilic odorants through the aqueous sensillum lymph to the receptor cells. The sensilla trichodea of the silkmoth Antheraea polyphemus are supplied with three types of receptor cells responding specifically to three pheromone components. The sensillum lymph of these sensilla contains three different types of PBPs. In this study, recombinant PBPs in various combinations with pheromone components were applied to the receptor cells via tip-opened sensilla during electrophysiological recordings. The responses of receptor cells were shown to depend on both the pheromone component and the PBP. Pheromone components artificially bound to particular PBPs elicited nerve impulses in receptor cell types which they do not activate under natural conditions. This is the first electrophysiological study to suggest that the PBPs contribute to the activation of receptor molecules" |
| Keywords: | Animals Carrier Proteins/*physiology Evoked Potentials/drug effects Insect Proteins/physiology Moths/*physiology Olfactory Receptor Neurons/drug effects/*physiology Pheromones/pharmacology/*physiology; |
| Notes: | "MedlinePophof, Blanka eng Research Support, Non-U.S. Gov't Germany 2002/11/27 Naturwissenschaften. 2002 Nov; 89(11):515-8. doi: 10.1007/s00114-002-0364-5. Epub 2002 Oct 12" |
