| Title: | Differential expression of odorant-binding protein genes in rat nasal glands: implications for odorant-binding proteinII as a possible pheromone transporter |
| Author(s): | Ohno K; Kawasaki Y; Kubo T; Tohyama M; |
| Address: | "Department of Oto-rhino-laryngology, Osaka University Medical School, Japan" |
| DOI: | 10.1016/0306-4522(95)00454-8 |
| ISSN/ISBN: | 0306-4522 (Print) 0306-4522 (Linking) |
| Abstract: | "We examined the distribution and ontogeny of two odorant-binding proteins in the rat at various stages of development from newborn to adult using northern blot and in situ hybridization methods. Our results demonstrated spatial segregation between odorant-binding protein and odorant-binding proteinII in nasal glandular tissues. Odorant-binding protein messenger RNA was expressed in the glandular system opening into the nasal vestibule, whereas odorant-binding proteinII messenger RNA was seen in the posterior glands of the nasal septum and in the vomeronasal glands. In addition, odorant-binding protein and odorant-binding proteinII messenger RNA levels increased during early postnatal stages with time courses that paralleled the anatomical development of the main olfactory system and the vomeronasal system, respectively. Our results suggest that odorant-binding proteinII functions as a pheromone transporter in the vomeronasal system" |
| Keywords: | "Animals Base Sequence Blotting, Northern Carrier Proteins/*metabolism Exocrine Glands/growth & development/*metabolism Female Gene Expression Regulation/physiology In Situ Hybridization Male Molecular Sequence Data Olfactory Mucosa/growth & development/*m;neuroscience;" |
| Notes: | "MedlineOhno, K Kawasaki, Y Kubo, T Tohyama, M eng 1996/03/01 Neuroscience. 1996 Mar; 71(2):355-66. doi: 10.1016/0306-4522(95)00454-8" |
