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Int J Environ Res Public Health

Title:		Exposure to Crude Oil-Related Volatile Organic Compounds Associated with Lung Function Decline in a Longitudinal Panel of Children
Author(s):		Noh SR; Kim JA; Cheong HK; Ha M; Jee YK; Park MS; Choi KH; Kim H; Cho SI; Choi K; Paek D;
Address:		"Department of Public Health and Environment, Kosin University, 194 Wachi-ro, Yeongdo-gu, Busan 49104, Republic of Korea. Department of Spatial & Environmental Planning, Chungnam Institute, 73-26 Yeonsuwon-gil, Gongju-si 32589, Republic of Korea. Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, Suwon-si 16419, Republic of Korea. Department of Preventive Medicine, Dankook University College of Medicine, 119 Dandae-ro, Dongnam-gu, Cheonan-si 31116, Republic of Korea. Department of Internal Medicine, Dankook University College of Medicine, 119 Dandae-ro, Dongnam-gu, Cheonan-si 31116, Republic of Korea. Institute of Environmental Medicine, Seoul National University Medical Research Center, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Institute of Health and Environment, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Division of Cancer Prevention, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si 10408, Republic of Korea"
Journal Title:		Int J Environ Res Public Health
Year:		2022
Volume:		20221124
Issue:		23
Page Number:		-
DOI:		10.3390/ijerph192315599
ISSN/ISBN:		1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking)
Abstract:		"BACKGROUND: Children in the affected area were exposed to large amounts of volatile organic compounds (VOCs) from the Hebei Spirit oil spill accident. OBJECTIVES: We investigated the lung function loss from the exposure to VOCs in a longitudinal panel of 224 children 1, 3, and 5 years after the VOC exposure event. METHODS: Atmospheric estimated concentration of total VOCs (TVOCs), benzene, toluene, ethylbenzene, and xylene for 4 days immediately after the accident were calculated for each village (n = 83) using a modeling technique. Forced expiratory volume in 1 s (FEV(1)) as an indicator of airway status was measured 1, 3, and 5 years after the exposure in 224 children 4~9 years of age at the exposure to the oil spill. Multiple linear regression and linear mixed models were used to evaluate the associations, with adjustment for smoking and second-hand smoke at home. RESULTS: Among the TVOCs (geometric mean: 1319.5 mg/m(3).4 d), xylene (9.4), toluene (8.5), ethylbenzene (5.2), and benzene (2.0) were dominant in the order of air concentration level. In 224 children, percent predicted FEV(1) (ppFEV(1)), adjusted for smoking and second-hand smoke at home, was 100.7% after 1 year, 96.2% after 3 years, and 94.6% after 5 years, and the loss over the period was significant (p < 0.0001). After 1 and 3 years, TVOCs, xylene, toluene, and ethylbenzene were significantly associated with ppFEV(1). After 5 years, the associations were not significant. Throughout the 5 years' repeated measurements in the panel, TVOCs, xylene, toluene, and ethylbenzene were significantly associated with ppFEV(1). CONCLUSIONS: Exposure to VOCs from the oil spill resulted in lung function loss among children, which remained significant up to 5 years after the exposure"
Keywords:		Child Humans *Volatile Organic Compounds/toxicity/analysis Benzene/analysis *Petroleum *Tobacco Smoke Pollution Benzene Derivatives/toxicity/analysis Xylenes/toxicity/analysis Toluene/toxicity/analysis Lung *Air Pollutants/analysis Environmental Monitorin;
Notes:		"MedlineNoh, Su Ryeon Kim, Jung-Ah Cheong, Hae-Kwan Ha, Mina Jee, Young-Koo Park, Myung-Sook Choi, Kyung-Hwa Kim, Ho Cho, Sung-Il Choi, Kyungho Paek, Domyung eng Research Support, Non-U.S. Gov't Switzerland 2022/12/12 Int J Environ Res Public Health. 2022 Nov 24; 19(23):15599. doi: 10.3390/ijerph192315599"