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Annu Rev Genet

Title:		"Genetics of Candida albicans, a diploid human fungal pathogen"
Author(s):		Noble SM; Johnson AD;
Address:		"Department of Microbiology and Immunology, University of California-San Francisco, CA 94143-2200, USA. Suzanne.Noble@ucsf.edu"
Journal Title:		Annu Rev Genet
Year:		2007
Volume:		41
Issue:
Page Number:		193 - 211
DOI:		10.1146/annurev.genet.41.042007.170146
ISSN/ISBN:		0066-4197 (Print) 0066-4197 (Linking)
Abstract:		"Candida albicans is a species of fungus that typically resides in the gastrointestinal tracts of humans and other warm-blooded animals. It is also the most common human fungal pathogen, causing a variety of skin and soft tissue infections in healthy people and more virulent invasive and disseminated diseases in patients with compromised immune systems. How this microorganism manages to persist in healthy hosts but also to cause a spectrum of disease states in the immunocompromised host are questions of significant biological interest as well as major clinical and economic importance. In this review, we describe recent developments in population genetics, the mating process, and gene disruption technology that are providing much needed experimental insights into the biology of C. albicans"
Keywords:		"Candida albicans/*genetics/pathogenicity *Diploidy *Genes, Fungal;"
Notes:		"MedlineNoble, Suzanne M Johnson, Alexander D eng K08 AI 062800/AI/NIAID NIH HHS/ R01 AI 49187/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review 2007/07/07 Annu Rev Genet. 2007; 41:193-211. doi: 10.1146/annurev.genet.41.042007.170146"