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Neurobiol Learn Mem

Title:		Different importance of the volatile and non-volatile fractions of an olfactory signature for individual social recognition in rats versus mice and short-term versus long-term memory
Author(s):		Noack J; Richter K; Laube G; Haghgoo HA; Veh RW; Engelmann M;
Address:		"Zentrum fur zellulare Bildgebung und Innovative Krankheitsmodelle, Otto-von-Guericke-Universitat, Leipziger Strasse 44, D-39120 Magdeburg, Germany. julia.noack@med.ovgu.de"
Journal Title:		Neurobiol Learn Mem
Year:		2010
Volume:		20101001
Issue:		4
Page Number:		568 - 575
DOI:		10.1016/j.nlm.2010.09.013
ISSN/ISBN:		1095-9564 (Electronic) 1074-7427 (Linking)
Abstract:		"When tested in the olfactory cued social recognition/discrimination test, rats and mice differ in their retention of a recognition memory for a previously encountered conspecific juvenile: Rats are able to recognize a given juvenile for approximately 45 min only whereas mice show not only short-term, but also long-term recognition memory (>/= 24 h). Here we modified the social recognition/social discrimination procedure to investigate the neurobiological mechanism(s) underlying the species differences. We presented a conspecific juvenile repeatedly to the experimental subjects and monitored the investigation duration as a measure for recognition. Presentation of only the volatile fraction of the juvenile olfactory signature was sufficient for both short- and long-term recognition in mice but not rats. Applying additional volatile, mono-molecular odours to the 'to be recognized' juveniles failed to affect short-term memory in both species, but interfered with long-term recognition in mice. Finally immunocytochemical analysis of c-Fos as a marker for cellular activation, revealed that juvenile exposure stimulated areas involved in the processing of olfactory signals in both the main and the accessory olfactory bulb in mice. In rats, we measured an increased c-Fos synthesis almost exclusively in cells of the accessory olfactory bulb. Our data suggest that the species difference in the retention of social recognition memory is based on differences in the processing of the volatile versus non-volatile fraction of the individuals' olfactory signature. The non-volatile fraction is sufficient for retaining a short-term social memory only. Long-term social memory - as observed in mice - requires a processing of both the volatile and non-volatile fractions of the olfactory signature"
Keywords:		"Age Factors Animals Behavior, Animal/physiology Discrimination Learning/physiology Male Memory, Long-Term/*physiology Memory, Short-Term/*physiology Mice Mice, Inbred C57BL Olfactory Bulb/*physiology Olfactory Pathways/physiology Olfactory Perception/*phy;"
Notes:		"MedlineNoack, Julia Richter, Karin Laube, Gregor Haghgoo, Hojjat Allah Veh, Rudiger W Engelmann, Mario eng Comparative Study Research Support, Non-U.S. Gov't 2010/10/05 Neurobiol Learn Mem. 2010 Nov; 94(4):568-75. doi: 10.1016/j.nlm.2010.09.013. Epub 2010 Oct 1"