| Title: | Functional MRI of the mouse olfactory system |
| Author(s): | Muir ER; Biju KC; Cong L; Rogers WE; Torres Hernandez E; Duong TQ; Clark RA; |
| Address: | "Research Imaging Institute, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States; Department of Ophthalmology, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States. Department of Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States. Research Imaging Institute, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States; Department of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, United States. Research Imaging Institute, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States. Research Imaging Institute, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States; Department of Ophthalmology, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States; South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX, 78229, United States. Department of Medicine, UT Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, United States; South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX, 78229, United States. Electronic address: CLARKRA@uthscsa.edu" |
| DOI: | 10.1016/j.neulet.2019.03.055 |
| ISSN/ISBN: | 1872-7972 (Electronic) 0304-3940 (Linking) |
| Abstract: | "Although olfactory dysfunction is an early warning sign of Alzheimer's and Parkinson's diseases, and is commonly present in a range of other neurodegenerative disorders, the mechanisms for its pathogenesis are not yet clear. Since fMRI allows the mapping of spatial and temporal patterns of activity in multiple brain regions simultaneously, it serves as a powerful tool to study olfactory dysfunction in animal models of neurodegenerative diseases. Nonetheless, there have been no reports to date of mapping odor-induced activation patterns beyond the olfactory bulb to the extended networks of olfactory and limbic archicortex, likely due to the small size of the mouse brain. Therefore, using an 11.7 T magnet and a blood volume-weighted fMRI technique, we mapped the functional neuroanatomy of the mouse olfactory system. Consistent with reports on imaging of the much larger human brain, we mapped activity in regions of the olfactory bulb, as well as olfactory and limbic archicortex. By using two distinct odorants, we further demonstrated odorant-specific activation patterns. Our work thus provides a methodological framework for fMRI studies of olfactory dysfunction in mouse models of neurodegeneration" |
| Keywords: | "Animals Brain Mapping Feasibility Studies Magnetic Resonance Imaging Male Mice, Inbred C57BL Odorants Olfactory Bulb/*physiology Olfactory Pathways/*physiology Odors Olfaction Olfactory bulb Olfactory cortex Pheromone fMRI;" |
| Notes: | "MedlineMuir, Eric R Biju, K C Cong, Linlin Rogers, William E Torres Hernandez, Enrique Duong, Timothy Q Clark, Robert A eng I01 BX003157/BX/BLRD VA/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Ireland 2019/04/06 Neurosci Lett. 2019 Jun 21; 704:57-61. doi: 10.1016/j.neulet.2019.03.055. Epub 2019 Apr 2" |
