| Title: | Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima |
| Author(s): | Metoyer B; Lebouvier N; Hnawia E; Thouvenot L; Wang F; Harinantenaina Rakotondraibe L; Raharivelomanana P; Asakawa Y; Nour M; |
| Address: | "Institut des Sciences Exactes et Appliquees (ISEA)-EA 4243, Universite de la Nouvelle-Caledonie, Noumea Cedex, Nouvelle-Caledonie, France. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. Independant Researcher, Pergignan, France. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA. Ecosystemes Insulaires Oceaniens (UMR EIO 241), University of French Polynesia, Faaa, French Polynesia" |
| DOI: | 10.1080/14786419.2019.1655022 |
| ISSN/ISBN: | 1478-6427 (Electronic) 1478-6419 (Linking) |
| Abstract: | The first chemotaxonomic study based on volatile components of Porella viridissima (Mitt.) Grolle is reported. The GC-MS analysis of ether extract was performed; ten santalane and five pinguisane-type sesquiterpenes were identified together with perrottetianal A as major diterpene. Most of detected santalane-type sesquiterpenes are reported for the first time in liverwort. P. viridissima was found to belong to the chemotype III (pinguisane/sacculatane) and shared chemical similarities with P. navicularis. Perrotettianal A was isolated and has shown strong cytotoxicity against ovarian cancer |
| Keywords: | "Antineoplastic Agents, Phytogenic/chemistry/*pharmacology Diterpenes/analysis/chemistry/pharmacology Drug Screening Assays, Antitumor Female Gas Chromatography-Mass Spectrometry Hepatophyta/*chemistry/*classification Humans Ovarian Neoplasms/drug therapy/;" |
| Notes: | "MedlineMetoyer, Benjamin Lebouvier, Nicolas Hnawia, Edouard Thouvenot, Louis Wang, Fengrui Harinantenaina Rakotondraibe, Liva Raharivelomanana, Phila Asakawa, Yoshinori Nour, Mohammed eng England 2019/08/24 Nat Prod Res. 2021 Jun; 35(12):2099-2102. doi: 10.1080/14786419.2019.1655022. Epub 2019 Aug 23" |
