| Title: | MK-801 and male odours induce c-fos expression in the AOB of juvenile female mice |
| Author(s): | McLellan RA; Wilkinson M; Brown RE; |
| Address: | "Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada" |
| DOI: | 10.1097/00001756-199812010-00028 |
| ISSN/ISBN: | 0959-4965 (Print) 0959-4965 (Linking) |
| Abstract: | "The odours of adult males, which accelerate the timing of puberty of female mice, activate c-fos in the accessory olfactory bulb (AOB). To test the hypothesis that NMDA receptors are involved in the male odour-induced increase in c-fos expression, we studied the effects of the non-competitive NMDA receptor agonist MK-801 on male odour-induced c-fos expression in the AOB of juvenile female mice. Surprisingly, MK-801 increased FOS-like immunoreactivity (FLI) within the AOB in the absence of male odour and had no effect on male odour-induced c-fos expression. We suggest that MK-801 increases AOB mitral cell activity by disinhibiting GABAergic granule cells, resulting in increased c-fos expression throughout the AOB" |
| Keywords: | Animals Dizocilpine Maleate/*pharmacology Excitatory Amino Acid Antagonists/*pharmacology Female Humans Immunohistochemistry Male Mice *Odorants Olfactory Bulb/*drug effects/metabolism Proto-Oncogene Proteins c-fos/*biosynthesis Sex Attractants/*pharmacol; |
| Notes: | "MedlineMcLellan, R A Wilkinson, M Brown, R E eng Research Support, Non-U.S. Gov't England 1999/01/06 Neuroreport. 1998 Dec 1; 9(17):3919-24. doi: 10.1097/00001756-199812010-00028" |
