| Title: | Males shorten the life span of C. elegans hermaphrodites via secreted compounds |
| Author(s): | Maures TJ; Booth LN; Benayoun BA; Izrayelit Y; Schroeder FC; Brunet A; |
| Address: | "Department of Genetics, Stanford University, Stanford, CA 94305, USA" |
| ISSN/ISBN: | 1095-9203 (Electronic) 0036-8075 (Print) 0036-8075 (Linking) |
| Abstract: | "How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males accelerated aging and shortened the life span of individuals of the opposite sex (hermaphrodites), including long-lived or sterile hermaphrodites. The male-induced demise could occur without mating and required only exposure of hermaphrodites to medium in which males were once present. Such communication through pheromones or other diffusible substances points to a nonindividual autonomous mode of aging regulation. The male-induced demise also occurred in other species of nematodes, suggesting an evolutionary conserved process whereby males may induce the disposal of the opposite sex to save resources for the next generation or to prevent competition from other males" |
| Keywords: | "Animals Biological Evolution Caenorhabditis elegans/drug effects/genetics/*physiology Caenorhabditis elegans Proteins/genetics Carrier Proteins/genetics Culture Media, Conditioned/metabolism/pharmacology Female Gene Expression Regulation Genes, Helminth/g;" |
| Notes: | "MedlineMaures, Travis J Booth, Lauren N Benayoun, Berenice A Izrayelit, Yevgeniy Schroeder, Frank C Brunet, Anne eng DP1AG044848/AG/NIA NIH HHS/ R01AG031198/AG/NIA NIH HHS/ T32HG000044/HG/NHGRI NIH HHS/ F32 AG037254/AG/NIA NIH HHS/ T32 GM008500/GM/NIGMS NIH HHS/ T32 HG000044/HG/NHGRI NIH HHS/ F32AG37254/AG/NIA NIH HHS/ R01 GM088290/GM/NIGMS NIH HHS/ R01 AG031198/AG/NIA NIH HHS/ T32GM008500/GM/NIGMS NIH HHS/ DP1 AG044848/AG/NIA NIH HHS/ R01GM088290/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/12/03 Science. 2014 Jan 31; 343(6170):541-4. doi: 10.1126/science.1244160. Epub 2013 Nov 29" |
