| Title: | Monitoring the Reaction of the Body State to Antibiotic Treatment against Helicobacter pylori via Infrared Spectroscopy: A Case Study |
| Address: | "Max Planck Institute for Quantum Optics, Hans-Kopfermann-Strasse 1, 85748 Garching, Germany. Department of Experimental Physics, Faculty of Physics, Ludwig-Maximilians-Universitat Munchen, Am Coulombwall 1, 85748 Garching, Germany. Institute of Automation and Electrometry SB RAS, 630090 Novosibirsk, Russia. Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia" |
| DOI: | 10.3390/molecules26113474 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "The current understanding of deviations of human microbiota caused by antibiotic treatment is poor. In an attempt to improve it, a proof-of-principle spectroscopic study of the breath of one volunteer affected by a course of antibiotics for Helicobacter pylori eradication was performed. Fourier transform spectroscopy enabled searching for the absorption spectral structures sensitive to the treatment in the entire mid-infrared region. Two spectral ranges were found where the corresponding structures strongly correlated with the beginning and end of the treatment. The structures were identified as methyl ester of butyric acid and ethyl ester of pyruvic acid. Both acids generated by bacteria in the gut are involved in fundamental processes of human metabolism. Being confirmed by other studies, measurement of the methyl butyrate deviation could be a promising way for monitoring acute gastritis and anti-Helicobacter pylori antibiotic treatment" |
| Keywords: | Anti-Bacterial Agents/chemistry/*therapeutic use Butyric Acid/chemistry Esters/chemistry Gastritis/drug therapy Gastrointestinal Microbiome/drug effects Helicobacter Infections/*drug therapy Helicobacter pylori/*drug effects Humans Male Middle Aged Pyruvi; |
| Notes: | "MedlineMaiti, Kiran Sankar Apolonski, Alexander eng Switzerland 2021/07/03 Molecules. 2021 Jun 7; 26(11):3474. doi: 10.3390/molecules26113474" |
