« Previous AbstractNeural mechanisms underlying the action of primer pheromones in mice    Next AbstractEffective induction of pregnancy block by electrical stimulation of the mouse accessory olfactory bulb coincident with prolactin surges »

Neuroscience

Title:		Cholecystokinin: critical role in mediating olfactory influences on reproduction
Author(s):		Li CS; Kaba H; Saito H; Seto K;
Address:		"Department of Physiology, Kochi Medical School, Japan"
Journal Title:		Neuroscience
Year:		1992
Volume:		48
Issue:		3
Page Number:		707 - 713
DOI:		10.1016/0306-4522(92)90413-v
ISSN/ISBN:		0306-4522 (Print) 0306-4522 (Linking)
Abstract:		"Our electrophysiological studies in female mice have demonstrated that electrical stimulation of the accessory olfactory bulb excites tuberoinfundibular dopaminergic arcuate neurons via the amygdala-stria terminalis route. This study shows that the medial preoptic area is identified as an additional relay for the excitatory transmission by examining the effectiveness of locally infused lignocaine anaesthetic in blocking the transmission and that of electrical stimulation in evoking a shorter latency response. Based on the known immunohistochemical findings, further attention is focused on a transmitter mediating synaptic transmission in the medial preoptic area. The cholecystokinin-B type receptor antagonist L-365,260 (0.3, 0.6, 0.9 pmol), but not the A type receptor antagonist L-364,718 (0.9 pmol), infused into the medial preoptic area, blocked the excitation of tuberoinfundibular arcuate neurons in a dose-dependent manner. Conversely, cholecystokinin octapeptide (0.6 pmol) increased firing activity in such neurons. The antagonizing effect of L-365,260 was reproduced in the context of the olfactory block to pregnancy: bilateral infusions of this drug into the medical preoptic area of recently mated females immediately before exposures to strange males' pheromones prevented them from inducing pregnancy block. These findings implicate cholecystokinin acting on cholecystokinin-B receptors in the medial preoptic area as a mediator of olfactory influences on reproductive physiology"
Keywords:		"Animals Benzodiazepinones/pharmacology Cholecystokinin/*physiology Devazepide Electrophysiology Estrus/physiology Female Male Mice Mice, Inbred BALB C Olfactory Pathways/physiology Ovariectomy *Phenylurea Compounds Preoptic Area/cytology/physiology Recept;"
Notes:		"MedlineLi, C S Kaba, H Saito, H Seto, K eng Research Support, Non-U.S. Gov't 1992/01/01 Neuroscience. 1992; 48(3):707-13. doi: 10.1016/0306-4522(92)90413-v"