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Neuroreport

Title:		Distribution of PDE4A and G(o) alpha immunoreactivity in the accessory olfactory system of the mouse
Author(s):		Lau YE; Cherry JA;
Address:		"Department of Psychology, Boston University, MA 02215, USA"
Journal Title:		Neuroreport
Year:		2000
Volume:		11
Issue:		1
Page Number:		27 - 32
DOI:		10.1097/00001756-200001170-00006
ISSN/ISBN:		0959-4965 (Print) 0959-4965 (Linking)
Abstract:		"Distribution of the cAMP-specific phosphodiesterase PDE4A was examined in the accessory olfactory system by immunohistochemistry. Adjacent sections through the vomeronasal organ (VNO) and accessory olfactory bulb (AOB) were alternately immunostained with antibodies against PDE4A or the G-protein alpha subunit G(o) alpha, which labels basal VNO neurons, in order to determine whether PDE4A occurs preferentially in one of two segregated VNO pathways. We found that PDE4A strongly labeled apical VNO neurons and rostral AOB glomeruli. There was virtually no overlap in G(o) alpha and PDE4A staining, and there were no regions of the VNO neuroepithelium or AOB glomeruli not labeled by either antibody. These results identify a potential member of the pheromone transduction cascade in apical neurons, and provide further evidence that the VNO consists of functionally distinct pathways"
Keywords:		"3', 5'-Cyclic-AMP Phosphodiesterases/*metabolism Animals Cyclic Nucleotide Phosphodiesterases, Type 4 Image Processing, Computer-Assisted Immunohistochemistry Mice Olfactory Bulb/cytology/enzymology/*metabolism Pheromones Signal Transduction/physiology Vom;"
Notes:		"MedlineLau, Y E Cherry, J A eng DC03019/DC/NIDCD NIH HHS/ MH59200/MH/NIMH NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 2000/02/23 Neuroreport. 2000 Jan 17; 11(1):27-32. doi: 10.1097/00001756-200001170-00006"