| Title: | Differential distribution of gamma-glutamyl cycle molecules in the vomeronasal organ of rats |
| Author(s): | Krishna NS; Getchell ML; Getchell TV; |
| Address: | "Department of Physiology and Biophysics, University of Kentucky College of Medicine, Lexington 40536" |
| DOI: | 10.1097/00001756-199207000-00001 |
| ISSN/ISBN: | 0959-4965 (Print) 0959-4965 (Linking) |
| Abstract: | "Molecules related to the gamma-glutamyl cycle, including thiols, glutathione (GSH) and gamma-glutamyl transpeptidase (gamma-GT) were identified histochemically and immunohistochemically in the vomeronasal organ of neonatal and adult rats. Thiols and GSH were distributed in the mucomicrovillar complex (MMC), vomeronasal receptor neurons and acinar cells of vomeronasal glands (VNG). gamma-GT was localized in the MMC and in the VNG, where it was associated mainly with the luminal surface of the acinar cells and ducts. The VNO of the neonates exhibited higher staining intensities for all compounds than that of the adults. The data indicate that components of the gamma-glutamyl cycle are present in the VNO and that they are secreted into mucus, where they may be associated with perireceptor events including clearance of pheromones and detoxification of xenobiotics" |
| Keywords: | "Aging/*metabolism Animals Animals, Newborn Epithelial Cells Epithelium/metabolism Glutathione/*metabolism Nasal Septum/cytology/growth & development/*metabolism Neurons/cytology/*metabolism Organ Specificity Rats Rats, Wistar Sulfhydryl Compounds/*metabol;" |
| Notes: | "MedlineKrishna, N S Getchell, M L Getchell, T V eng DC-00159/DC/NIDCD NIH HHS/ Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. England 1992/07/01 Neuroreport. 1992 Jul; 3(7):551-4. doi: 10.1097/00001756-199207000-00001" |
