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Genetics

Title:		Caenorhabditis elegans SDF-9 enhances insulin/insulin-like signaling through interaction with DAF-2
Author(s):		Jensen VL; Albert PS; Riddle DL;
Address:		"Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"
Journal Title:		Genetics
Year:		2007
Volume:		20070729
Issue:		1
Page Number:		661 - 666
DOI:		10.1534/genetics.107.076703
ISSN/ISBN:		0016-6731 (Print) 0016-6731 (Linking)
Abstract:		"SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling"
Keywords:		"Animals Animals, Genetically Modified Caenorhabditis elegans/*genetics/growth & development/metabolism Caenorhabditis elegans Proteins/genetics/*metabolism Hypoglycemic Agents/pharmacology Insulin/*pharmacology Insulin-Like Growth Factor I/*metabolism Mut;"
Notes:		"MedlineJensen, Victor L Albert, Patrice S Riddle, Donald L eng Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2007/07/31 Genetics. 2007 Sep; 177(1):661-6. doi: 10.1534/genetics.107.076703. Epub 2007 Jul 29"