| Title: | Colorectal Cancer Study with Nanostructured Sensors: Tumor Marker Screening of Patient Biopsies |
| Author(s): | Astolfi M; Rispoli G; Anania G; Nevoso V; Artioli E; Landini N; Benedusi M; Melloni E; Secchiero P; Tisato V; Zonta G; Malagu C; |
| Address: | "Department of Physics and Earth Sciences, University of Ferrara, Via Saragat 1/C, 44122 Ferrara, Italy. SCENT S.r.l (SME company), Via Quadrifoglio 11, 44124 Ferrara, Italy. Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy" |
| ISSN/ISBN: | 2079-4991 (Print) 2079-4991 (Electronic) 2079-4991 (Linking) |
| Abstract: | "Despite the great progress in screening techniques and medical treatments, colorectal cancer remains one of the most widespread cancers in both sexes, with a high death rate. In this work, the volatile compounds released from human colon cancer tissues were detected by a set of four different chemoresistive sensors, made with a nanostructured powder of metal-oxide materials, inserted into an innovative patented device. The sensor responses to the exhalation of a primary cancer sample and of a healthy sample (both of the same weight, collected during colorectal surgery from the intestine of the same patient) were statistically analyzed. The sensors gave reversible, reproducible, and fast responses for at least one year of continuous use, making them quite superior in respect to the existing diagnostic methods. Preliminary results obtained using principal component analysis of the sensor responses to samples removed from 13 patients indicate that the nanostructured sensors employed in this study were able to distinguish between healthy and tumor tissue samples with coherent responses (the discrimination power of the most sensitive sensor was about 17%), highlighting a strong potential for clinical practice" |
| Keywords: | chemoresistivity colorectal cancer human cancer biopsies nanostructured sensors tumor markers volatile organic compounds; |
| Notes: | "PubMed-not-MEDLINEAstolfi, Michele Rispoli, Giorgio Anania, Gabriele Nevoso, Veronica Artioli, Elena Landini, Nicolo Benedusi, Mascia Melloni, Elisabetta Secchiero, Paola Tisato, Veronica Zonta, Giulia Malagu, Cesare eng Switzerland 2020/04/01 Nanomaterials (Basel). 2020 Mar 26; 10(4):606. doi: 10.3390/nano10040606" |
