| Title: | Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans |
| Author(s): | Jang H; Kim K; Neal SJ; Macosko E; Kim D; Butcher RA; Zeiger DM; Bargmann CI; Sengupta P; |
| Address: | "Howard Hughes Medical Institute and Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA" |
| DOI: | 10.1016/j.neuron.2012.06.034 |
| ISSN/ISBN: | 1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking) |
| Abstract: | "Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to 'social' hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons. The ADL sensory neurons detect C9 and, in wild-type hermaphrodites, drive C9 repulsion through their chemical synapses. In npr-1 mutant hermaphrodites, C9 repulsion is reduced by the recruitment of a gap junction circuit that antagonizes ADL chemical synapses. In males, ADL sensory responses are diminished; in addition, a second pheromone-sensing neuron, ASK, antagonizes C9 repulsion. The additive effects of these antagonistic circuit elements generate attractive, repulsive, or neutral pheromone responses. Neuronal modulation by circuit state and sex, and flexibility in synaptic output pathways, may permit small circuits to maximize their adaptive behavioral outputs" |
| Keywords: | "Analysis of Variance Animals Animals, Genetically Modified Caenorhabditis elegans/*drug effects/physiology Caenorhabditis elegans Proteins/genetics Calcium/metabolism Complement C9/pharmacology Dose-Response Relationship, Drug Drug Interactions Escape Rea;" |
| Notes: | "MedlineJang, Heeun Kim, Kyuhyung Neal, Scott J Macosko, Evan Kim, Dongshin Butcher, Rebecca A Zeiger, Danna M Bargmann, Cornelia I Sengupta, Piali eng UL1 TR000064/TR/NCATS NIH HHS/ P30 NS45713/NS/NINDS NIH HHS/ HHMI/Howard Hughes Medical Institute/ R00 GM087533/GM/NIGMS NIH HHS/ F31 DC011467/DC/NIDCD NIH HHS/ R25 MH094612/MH/NIMH NIH HHS/ P30 NS045713/NS/NINDS NIH HHS/ R00 GM87533/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2012/08/28 Neuron. 2012 Aug 23; 75(4):585-92. doi: 10.1016/j.neuron.2012.06.034" |
