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Semin Cell Biol

Title:		Control of signal transduction and morphogenesis by Ras
Author(s):		Hughes DA;
Address:		"CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK"
Journal Title:		Semin Cell Biol
Year:		1995
Volume:		6
Issue:		2
Page Number:		89 - 94
DOI:		10.1016/1043-4682(95)90005-5
ISSN/ISBN:		1043-4682 (Print) 1043-4682 (Linking)
Abstract:		"The single Ras homologue (Ras1) of S. pombe regulates two distinct processes: (1) Signal transduction through a MAP kinase-like protein kinase cascade in response to mating pheromones. In this pathway Ras1 interacts with the protein kinase Byr2 and leads to its activation in conjunction with a signal from the receptor-coupled, heterotrimeric G protein. (2) Polarized cell growth both during the cell cycle and during directed cell extension towards a mating partner. Ras1 interacts with Ral1/Scd1, a putative guanine-nucleotide-exchange factor, which could activate Cdc42, Rho-like GTP-binding protein. Cdc42 may regulate the dynamics of the actin cytoskeleton"
Keywords:		"Amino Acid Sequence DNA-Binding Proteins Eukaryotic Cells/physiology Fungal Proteins/*physiology GTP-Binding Proteins/*physiology Genes, Fungal *Genes, ras Guanosine Triphosphate/physiology Intercellular Signaling Peptides and Proteins Molecular Sequence;"
Notes:		"MedlineHughes, D A eng Comparative Study Review England 1995/04/01 Semin Cell Biol. 1995 Apr; 6(2):89-94. doi: 10.1016/1043-4682(95)90005-5"