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Nature

Title:		Hunger enhances food-odour attraction through a neuropeptide Y spotlight
Author(s):		Horio N; Liberles SD;
Address:		"Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Stephen_Liberles@hms.harvard.edu"
Journal Title:		Nature
Year:		2021
Volume:		20210303
Issue:		7853
Page Number:		262 - 266
DOI:		10.1038/s41586-021-03299-4
ISSN/ISBN:		1476-4687 (Electronic) 0028-0836 (Print) 0028-0836 (Linking)
Abstract:		"Internal state controls olfaction through poorly understood mechanisms. Odours that represent food, mates, competitors and predators activate parallel neural circuits that may be flexibly shaped by physiological need to alter behavioural outcome(1). Here we identify a neuronal mechanism by which hunger selectively promotes attraction to food odours over other olfactory cues. Optogenetic activation of hypothalamic agouti-related peptide (AGRP) neurons enhances attraction to food odours but not to pheromones, and branch-specific activation and inhibition reveal a key role for projections to the paraventricular thalamus. Mice that lack neuropeptide Y (NPY) or NPY receptor type 5 (NPY5R) fail to prefer food odours over pheromones after fasting, and hunger-dependent food-odour attraction is restored by cell-specific NPY rescue in AGRP neurons. Furthermore, acute NPY injection immediately rescues food-odour preference without additional training, indicating that NPY is required for reading olfactory circuits during behavioural expression rather than writing olfactory circuits during odour learning. Together, these findings show that food-odour-responsive neurons comprise an olfactory subcircuit that listens to hunger state through thalamic NPY release, and more generally, provide mechanistic insights into how internal state regulates behaviour"
Keywords:		"Agouti-Related Protein/metabolism Animals Female *Food Hunger/*physiology Hypothalamus/cytology/metabolism Male Mice Neurons/metabolism Neuropeptide Y/*metabolism *Odorants Optogenetics Pheromones/metabolism Receptors, Neuropeptide Y/metabolism;"
Notes:		"MedlineHorio, Nao Liberles, Stephen D eng R01 DC013289/DC/NIDCD NIH HHS/ U54 HD090255/HD/NICHD NIH HHS/ HHMI/Howard Hughes Medical Institute/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2021/03/05 Nature. 2021 Apr; 592(7853):262-266. doi: 10.1038/s41586-021-03299-4. Epub 2021 Mar 3"