| Title: | Determining the effective dimensionality of the genetic variance-covariance matrix |
| Address: | "School of Integrative Biology, University of Queensland, Brisbane 4072, Australia. ehine@zen.uq.edu.au" |
| DOI: | 10.1534/genetics.105.054627 |
| ISSN/ISBN: | 0016-6731 (Print) 0016-6731 (Linking) |
| Abstract: | "Determining the dimensionality of G provides an important perspective on the genetic basis of a multivariate suite of traits. Since the introduction of Fisher's geometric model, the number of genetically independent traits underlying a set of functionally related phenotypic traits has been recognized as an important factor influencing the response to selection. Here, we show how the effective dimensionality of G can be established, using a method for the determination of the dimensionality of the effect space from a multivariate general linear model introduced by Amemiya (1985). We compare this approach with two other available methods, factor-analytic modeling and bootstrapping, using a half-sib experiment that estimated G for eight cuticular hydrocarbons of Drosophila serrata. In our example, eight pheromone traits were shown to be adequately represented by only two underlying genetic dimensions by Amemiya's approach and factor-analytic modeling of the covariance structure at the sire level. In contrast, bootstrapping identified four dimensions with significant genetic variance. A simulation study indicated that while the performance of Amemiya's method was more sensitive to power constraints, it performed as well or better than factor-analytic modeling in correctly identifying the original genetic dimensions at moderate to high levels of heritability. The bootstrap approach consistently overestimated the number of dimensions in all cases and performed less well than Amemiya's method at subspace recovery" |
| Keywords: | "Animals Databases, Genetic Drosophila/genetics *Genetic Variation Linear Models *Models, Genetic Models, Statistical Phenotype;" |
| Notes: | "MedlineHine, Emma Blows, Mark W eng Comparative Study Research Support, Non-U.S. Gov't 2006/03/21 Genetics. 2006 Jun; 173(2):1135-44. doi: 10.1534/genetics.105.054627. Epub 2006 Mar 17" |
