| Title: | Anxiolytic and hypnotic effects in mice of roasted coffee bean volatile compounds |
| Author(s): | Hayashi Y; Sogabe S; Hattori Y; Tanaka J; |
| Address: | "Department of Foods and Human Nutrition, Faculty of Human Life Sciences, Notre Dame Seishin University, 2-16-9 Ifuku-cho, Kita-Ku, Okayama 700-8516, Japan. yhayashi@post.ndsu.ac.jp" |
| DOI: | 10.1016/j.neulet.2012.10.044 |
| ISSN/ISBN: | 1872-7972 (Electronic) 0304-3940 (Linking) |
| Abstract: | "To clarify the relationship between the volatile compounds present in roasted coffee beans and psychological stress, we investigated the stress-reducing potential of coffee volatiles in mice using a variety of behavioral pharmacology methods. In the elevated plus-maze test, exposure to coffee volatiles increased the time spent in and the number of entries into the open arms without increasing spontaneous locomotor activity. Pentobarbital-induced sleep time was prolonged by volatile exposure. No significant effects were detected in the open-field or forced-swim tests. These results suggest that coffee volatiles lower the arousal level and exert anti-anxiety-like, stress-reducing effects in mice" |
| Keywords: | "Animals Anti-Anxiety Agents/*pharmacology Behavior, Animal/*drug effects Coffea/*chemistry Hypnotics and Sedatives/*pharmacology Male Maze Learning/drug effects Mice Mice, Inbred ICR Seeds/*chemistry Stress, Psychological Volatile Organic Compounds/pharma;" |
| Notes: | "MedlineHayashi, Yasushi Sogabe, Saki Hattori, Yukio Tanaka, Junichi eng Research Support, Non-U.S. Gov't Ireland 2012/11/07 Neurosci Lett. 2012 Dec 7; 531(2):166-9. doi: 10.1016/j.neulet.2012.10.044. Epub 2012 Nov 2" |
