| Title: | Association Between Earwax-Determinant Genotypes and Acquired Middle Ear Cholesteatoma in a Japanese Population |
| Author(s): | Hara S; Kusunoki T; Nakagawa H; Toyoda Y; Nojiri S; Kamiya K; Furukawa M; Takata Y; Okada H; Anzai T; Matsumoto F; Ikeda K; |
| Address: | "Department of Otorhinolaryngology, Graduate School of Medicine, Juntendo University, Tokyo, Japan. Department of Otorhinolaryngology, Faculty of Medicine, Juntendo University, Tokyo, Japan. Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, Japan. Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan. Medical Technology Innovation Center, Juntendo University, Tokyo, Japan" |
| Journal Title: | Otolaryngol Head Neck Surg |
| DOI: | 10.1177/01945998211000374 |
| ISSN/ISBN: | 1097-6817 (Electronic) 0194-5998 (Linking) |
| Abstract: | "OBJECTIVE: A single-nucleotide polymorphism 538G>A in the human ABCC11 gene is a determinant of the earwax morphotype. ABCC11 538GG and GA correspond to wet earwax and 538AA to dry earwax. Despite a putative positive correlation between the frequency of the 538G allele and the prevalence of cholesteatoma, minimal clinical information is currently available. We aimed to evaluate this association between the ABCC11 genotypes and acquired middle ear cholesteatoma. STUDY DESIGN: Case-control study. SETTING: Single-center academic hospital. METHODS: We recruited 67 Japanese patients with acquired middle ear cholesteatoma (cholesteatoma group) and 100 Japanese controls with no history of middle ear cholesteatoma. We assessed the ABCC11 genotypes for all participants. Clinical information was collected from the cholesteatoma group. The genotype data of 104 Japanese people from the 1000 Genomes Project who represent the general population were used. RESULTS: The proportion of participants with ABCC11 538GG or GA was significantly higher in the cholesteatoma group than in the control group or general Japanese population (P < .001). The ABCC11 538G allele frequency was also significantly higher in the cholesteatoma group than in the control group or general Japanese population (P < .001). Multivariate logistic regression analyses revealed a significant association between the ABCC11 genotype and acquired middle ear cholesteatoma (odds ratio, 5.49; 95% CI, 2.61-11.5; P < .001). CONCLUSION: Our results suggest that the ABCC11 genotypes could be associated with the development of acquired middle ear cholesteatoma among Japanese people" |
| Keywords: | "ATP-Binding Cassette Transporters/*genetics Adult Aged Asian People/*genetics Case-Control Studies *Cerumen Cholesteatoma, Middle Ear/*genetics Female *Genotype Humans Japan Logistic Models Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide/*gene;" |
| Notes: | "MedlineHara, Satoshi Kusunoki, Takeshi Nakagawa, Hiroshi Toyoda, Yu Nojiri, Shuko Kamiya, Kazusaku Furukawa, Masayuki Takata, Yusuke Okada, Hiroko Anzai, Takashi Matsumoto, Fumihiko Ikeda, Katsuhisa eng Observational Study Research Support, Non-U.S. Gov't England 2021/03/17 Otolaryngol Head Neck Surg. 2022 Jan; 166(1):139-145. doi: 10.1177/01945998211000374. Epub 2021 Mar 16" |
