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J AOAC Int

Title:		Comparison and Discrimination of Artemisia argyi and Artemisia lavandulifolia by Gas Chromatography-Mass Spectrometry-Based Metabolomic Approach
Author(s):		Guo L; Zhang D; Wang L; Xue Z; Guo M; Duan L; Zheng Y;
Address:		"Hebei University of Chinese Medicine, School of Pharmacy, Shijiazhuang, China, 050200. Hebei Normal University, College of Chemistry and Material Science, Shijiazhuang, China, 050024"
Journal Title:		J AOAC Int
Year:		2019
Volume:		20190709
Issue:		6
Page Number:		1814 - 1821
DOI:		10.5740/jaoacint.19-0080
ISSN/ISBN:		1944-7922 (Electronic) 1060-3271 (Linking)
Abstract:		"Background: Artemisia argyi and A. lavandulifolia are two morphologically similar herbal medicines derived from the Artemisia genus. Although the two Artemisia herbs have been used as herbal medicines for a long time, studies on their phytochemicals and bioactive compositions are still limited, and no research has been devoted to compare the volatile compounds in A. argyi and A. lavandulifolia. Objective: To compare the volatile constituents in A. argyi and A. lavandulifolia and to explore chemical markers for discrimination and quality evaluation of the two Artemisia herbal medicines. Methods: A GC-MS-based metabolomic approach was employed to compare and discriminate A. argyi and A. lavandulifolia from the aspect of volatile compounds. Multivariate statistical methods, including principal component analysis and orthogonal partial least-squares discriminate analysis, were applied to explore chemical markers for discrimination of the two Artemisia herbal medicines. Results: Thirty volatile compounds were identified, and the chemical profiles of volatile compounds in A. argyi and A. lavandulifolia were quite similar. Principal component analysis and orthogonal partial least-squares discrimination analysis results indicated that the two Artemisia herbal medicines could be distinguished effectively from each other. Ten volatile compounds were selected as potential chemical markers for discrimination of the two Artemisia herbal medicines. Conclusions: The GC-MS-based metabolomics could be an acceptable strategy for comparison and discrimination of A. argyi and A. lavandulifolia as well as authentication of herbal medicines derived from other closely related species. Highlights: GC-MS based metabolomic approach was firstly applied to compare and discriminate Artemisia argyi and Artemisia lavandulifolia"
Keywords:		Artemisia/*classification Discriminant Analysis Gas Chromatography-Mass Spectrometry/methods Least-Squares Analysis Metabolomics/methods Principal Component Analysis Volatile Organic Compounds/*analysis;
Notes:		"MedlineGuo, Long Zhang, Dan Wang, Lei Xue, Zijing Guo, Mei Duan, Li Zheng, Yuguang eng England 2019/07/11 J AOAC Int. 2019 Nov 1; 102(6):1814-1821. doi: 10.5740/jaoacint.19-0080. Epub 2019 Jul 9"