| Title: | "Hierarchical cluster analysis and chemical characterisation of Myrtus communis L. essential oil from Yemen region and its antimicrobial, antioxidant and anti-colorectal adenocarcinoma properties" |
| Author(s): | Anwar S; Crouch RA; Awadh Ali NA; Al-Fatimi MA; Setzer WN; Wessjohann L; |
| Address: | "a Department of Medicinal Chemistry , College of Clinical Pharmacy, Albaha University , Albaha , KSA. b Department of Chemistry , University of Alabama in Huntsville , Huntsville , AL , USA. c Department of Pharmacognosy , College of Clinical Pharmacy, Albaha University , Albaha , KSA. d Pharmacognosy Department, Faculty of Pharmacy , Aden University , Aden , Yemen. e Department of Bio-organic Chemistry , Leibniz Institute of Plant Biochemistry , Halle/Saale , Germany" |
| DOI: | 10.1080/14786419.2016.1277346 |
| ISSN/ISBN: | 1478-6427 (Electronic) 1478-6419 (Linking) |
| Abstract: | "The hydrodistilled essential oil obtained from the dried leaves of Myrtus communis, collected in Yemen, was analysed by GC-MS. Forty-one compounds were identified, representing 96.3% of the total oil. The major constituents of essential oil were oxygenated monoterpenoids (87.1%), linalool (29.1%), 1,8-cineole (18.4%), alpha-terpineol (10.8%), geraniol (7.3%) and linalyl acetate (7.4%). The essential oil was assessed for its antimicrobial activity using a disc diffusion assay and resulted in moderate to potent antibacterial and antifungal activities targeting mainly Bacillus subtilis, Staphylococcus aureus and Candida albicans. The oil moderately reduced the diphenylpicrylhydrazyl radical (IC(50) = 4.2 muL/mL or 4.1 mg/mL). In vitro cytotoxicity evaluation against HT29 (human colonic adenocarcinoma cells) showed that the essential oil exhibited a moderate antitumor effect with IC(50) of 110 +/- 4 mug/mL. Hierarchical cluster analysis of M. communis has been carried out based on the chemical compositions of 99 samples reported in the literature, including Yemeni sample" |
| Keywords: | "Acyclic Monoterpenes Anti-Infective Agents/chemistry/*pharmacology Antineoplastic Agents, Phytogenic/chemistry/*pharmacology Antioxidants/analysis/chemistry/*pharmacology Bacillus subtilis/drug effects Candida albicans/drug effects Cluster Analysis Cycloh;" |
| Notes: | "MedlineAnwar, Sirajudheen Crouch, Rebecca A Awadh Ali, Nasser A Al-Fatimi, Mohamed A Setzer, William N Wessjohann, Ludger eng England 2017/01/11 Nat Prod Res. 2017 Sep; 31(18):2158-2163. doi: 10.1080/14786419.2016.1277346. Epub 2017 Jan 9" |
