| Title: | Comparison of volatile organic compound profiles in exhaled breath versus plasma headspace in different diseases |
| Author(s): | Grove D; Miller-Atkins G; Melillo C; Rieder F; Kurada S; Rotroff DM; Tonelli AR; Dweik RA; |
| Address: | "Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Print) 1752-7155 (Linking) |
| Abstract: | "Breath analysis is the study of volatile organic compounds (VOC's) in exhaled breath. This analysis provides information on the body's condition. In this study we investigated the relationship between 22 VOC's detected in exhaled breath and plasma headspace using a selected ion flow tube mass spectrometer (SYFT-MS). We compared pairs of exhaled breath and plasma samples from patients with pulmonary hypertension inflammatory bowel disease (IBD), and IBD patients after J-pouch surgery (pouch group). Half of the measured VOC's from exhaled breath were significantly associated with the VOC's from plasma headspace. Interestingly, six breath VOC's (trimethyl amine (FDR p = 0.02), hydrogen sulfide (FDR p = 7.64 x 10(-30)), ethanol (FDR p = 1.56 x 10(-4)), dimethyl sulfide (FDR p = 5.70 x 10(-19)), benzene (FDR p = 8.40 x 10(-27)), and acetaldehyde (FDR p = 4.27 x 10(-17))) and two plasma headspace VOC's (1-Octene (FDR p = 0.02) and 2-propanol (FDR p = 2.47 x 10(-9))) were able to differentiate between the three groups. Breath and plasma headspace share a similar signature with significant association in half of the measured VOCs. The disease discriminatory capacity of breath and plasma headspace appear to be different. Therefore, using the VOC's print from both breath and plasma headspace may better help diagnose patients" |
| Keywords: | Adult *Breath Tests *Disease *Exhalation Female Humans Male Volatile Organic Compounds/*blood; |
| Notes: | "MedlineGrove, David Miller-Atkins, Galen Melillo, Celia Rieder, Florian Kurada, Satya Rotroff, Daniel M Tonelli, Adriano R Dweik, Raed A eng K08 DK110415/DK/NIDDK NIH HHS/ R01 HL130307/HL/NHLBI NIH HHS/ Comparative Study England 2020/04/10 J Breath Res. 2020 May 27; 14(3):036003. doi: 10.1088/1752-7163/ab8866" |
