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J Am Assoc Lab Anim Sci

Title:		Effect of Room Ventilation Rates in Rodent Rooms with Direct-Exhaust IVC Systems
Author(s):		Geertsema RS; Lindsell CE;
Address:		"University Laboratory Animal Resources, University of California, Irvine, California, USA. roger.geertsema@rgs.uci.edu. University Laboratory Animal Resources, University of California, Irvine, California, USA"
Journal Title:		J Am Assoc Lab Anim Sci
Year:		2015
Volume:		54
Issue:		5
Page Number:		521 - 526
DOI:
ISSN/ISBN:		2769-6677 (Electronic) 1559-6109 (Print) 1559-6109 (Linking)
Abstract:		"When IVC are directly exhausted from a rodent housing room, the air quality of the room can become independent of the intracage air quality and may reduce the need for high room ventilation rates. This study assessed the effect of decreasing the ventilation rate in rodent rooms using direct-exhaust IVC systems. The study was conducted over 16 wk and compared conditions in 8 rodent rooms that had ventilation rates of 5 to 6 air changes per hour (ACH) with those in rooms at 10 to 12 ACH. At the low ventilation rate, rooms had higher CO(2) concentrations, higher dew point temperature, and lower particulate levels and spent a greater percentage of time above the temperature set point than did rooms at the high rate. The levels of allergens and endotoxins in room air were the same regardless of the ventilation rate. Differences seen in parameters within cages at the 2 ventilation rates were operationally irrelevant. We detected no total volatile organic compounds in the room that were attributable to ammonia, regardless of the ventilation rate. Clearing the air of ethanol after a spill took longer at the low compared with high rate. However, ethanol clearance was faster at the low rate when the demand-control system was activated than at the high ventilation rate alone. Air quality in the room and in the cages were acceptable with room ventilation rates of 5 to 6 ACH in rodent rooms that use direct-exhaust IVC systems"
Keywords:		"Air Pollution, Indoor Allergens/analysis Ammonia/analysis Animals *Animals, Laboratory *Housing, Animal *Mice *Rats Ventilation;"
Notes:		"MedlineGeertsema, Roger S Lindsell, Claire E eng Research Support, Non-U.S. Gov't 2015/10/02 J Am Assoc Lab Anim Sci. 2015 Sep; 54(5):521-6"