« Previous AbstractGenetic and physiological analysis of conjugation in Streptococcus faecalis    Next AbstractInduction of surface exclusion (entry exclusion) by Streptococcus faecalis sex pheromones: use of monoclonal antibodies to identify an inducible surface antigen involved in the exclusion process »

Proc Natl Acad Sci U S A

Title:		Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone
Author(s):		Dunny GM; Brown BL; Clewell DB;
Address:
Journal Title:		Proc Natl Acad Sci U S A
Year:		1978
Volume:		75
Issue:		7
Page Number:		3479 - 3483
DOI:		10.1073/pnas.75.7.3479
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"Recipient strains of Streptococcus faecalis produce a trypsin sensitive, heat resistant, nuclease resistant factor, designated clumping-inducing agent (CIA) which causes strains carrying certain conjugative plasmids to aggregate. RNA and protein synthesis but not DNA synthesis are required for aggregation to occur. Recipient filtrates that contain CIA activity also induce donors to mate at high frequencies. Introduction of a transferable plasmid into strains producing CIA dramatically reduces the amount of CIA activity produced by the strain but allows the strain to respond to exogenously added CIA. Our data suggest that CIA represents a bacterial sex hormone (pheromone)"
Keywords:		"Animals Bacterial Proteins/physiology Cell Membrane/physiology *Conjugation, Genetic Enterococcus faecalis/*physiology Pheromones/physiology Plasmids;"
Notes:		"MedlineDunny, G M Brown, B L Clewell, D B eng Research Support, U.S. Gov't, P.H.S. 1978/07/01 Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3479-83. doi: 10.1073/pnas.75.7.3479"