| Title: | Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition |
| Author(s): | Doncic A; Atay O; Valk E; Grande A; Bush A; Vasen G; Colman-Lerner A; Loog M; Skotheim JM; |
| Address: | "Department of Biology, Stanford University, Stanford, CA 94305, USA. Institute of Technology, University of Tartu, 50411, Estonia. IFIBYNE-UBA-CONICET and Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina. Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: skotheim@stanford.edu" |
| DOI: | 10.1016/j.cell.2015.02.032 |
| ISSN/ISBN: | 1097-4172 (Electronic) 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the regulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subsequent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feedback-driven yeast G1/S switch enables the transmission of memory of past pheromone exposure across this transition. We expect this to be one of many examples where the exquisite spatial organization of the eukaryotic cell enables previously well-characterized network motifs to perform new and unexpected signal processing functions" |
| Keywords: | "Cell Cycle Proteins/metabolism Cyclin-Dependent Kinase Inhibitor Proteins/metabolism Cyclins/metabolism Cytoplasm/metabolism Feedback, Physiological Guanine Nucleotide Exchange Factors/metabolism Pheromones/metabolism Saccharomyces cerevisiae/*cytology/*p;" |
| Notes: | "MedlineDoncic, Andreas Atay, Oguzhan Valk, Ervin Grande, Alicia Bush, Alan Vasen, Gustavo Colman-Lerner, Alejandro Loog, Mart Skotheim, Jan M eng R01 GM092925/GM/NIGMS NIH HHS/ GM097479/GM/NIGMS NIH HHS/ R01 GM097479/GM/NIGMS NIH HHS/ GM092925/GM/NIGMS NIH HHS/ P50 GM107615/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2015/03/15 Cell. 2015 Mar 12; 160(6):1182-95. doi: 10.1016/j.cell.2015.02.032" |
