| Title: | "The Harderian gland transcriptomes of Caraiba andreae, Cubophis cantherigerus and Tretanorhinus variabilis, three colubroid snakes from Cuba" |
| Author(s): | Dominguez-Perez D; Durban J; Aguero-Chapin G; Lopez JT; Molina-Ruiz R; Almeida D; Calvete JJ; Vasconcelos V; Antunes A; |
| Address: | "CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixoes, Av. General Norton de Matos, s/n, Porto 4450-208, Portugal; Department of Biology, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address: danydguezperez@gmail.com. Evolutionary and Translational Venomics Laboratory, CSIC, Jaume Roig, 11, 46010, Valencia, Spain. Electronic address: jdurban@ibv.csic.es. CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixoes, Av. General Norton de Matos, s/n, Porto 4450-208, Portugal; Department of Biology, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address: gchapin@ciimar.up.pt. Department of Ecology and Evolutionary Biology, The University of Kansas, 1345 Jayhawk Blvd., Lawrence, Kansas 66045, USA; Faculty of Biology, University of Havana, 25 St. 455, La Habana 10400, Cuba. Electronic address: javiertorres@ku.edu. Centro de Bioactivos Quimicos, Universidad Central 'Marta Abreu' de Las Villas, 54830 Santa Clara, Cuba. Electronic address: reymolina@uclv.edu.cu. CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixoes, Av. General Norton de Matos, s/n, Porto 4450-208, Portugal; Department of Biology, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address: danielaalmeida23@gmail.com. Evolutionary and Translational Venomics Laboratory, CSIC, Jaume Roig, 11, 46010, Valencia, Spain. Electronic address: jcalvete@ibv.csic.es. CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixoes, Av. General Norton de Matos, s/n, Porto 4450-208, Portugal; Department of Biology, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address: vmvascon@fc.up.pt. CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leixoes, Av. General Norton de Matos, s/n, Porto 4450-208, Portugal; Department of Biology, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address: aantunes@ciimar.up.pt" |
| DOI: | 10.1016/j.ygeno.2018.11.026 |
| ISSN/ISBN: | 1089-8646 (Electronic) 0888-7543 (Linking) |
| Abstract: | "The Harderian gland is a cephalic structure, widely distributed among vertebrates. In snakes, the Harderian gland is anatomically connected to the vomeronasal organ via the nasolacrimal duct, and in some species can be larger than the eyes. The function of the Harderian gland remains elusive, but it has been proposed to play a role in the production of saliva, pheromones, thermoregulatory lipids and growth factors, among others. Here, we have profiled the transcriptomes of the Harderian glands of three non-front-fanged colubroid snakes from Cuba: Caraiba andreae (Cuban Lesser Racer); Cubophis cantherigerus (Cuban Racer); and Tretanorhinus variabilis (Caribbean Water Snake), using Illumina HiSeq2000 100?ª+bp paired-end. In addition to ribosomal and non-characterized proteins, the most abundant transcripts encode putative transport/binding, lipocalin/lipocalin-like, and bactericidal/permeability-increasing-like proteins. Transcripts coding for putative canonical toxins described in venomous snakes were also identified. This transcriptional profile suggests a more complex function than previously recognized for this enigmatic organ" |
| Keywords: | Animals Colubridae/genetics/*metabolism Cuba Gene Expression Regulation/*physiology Harderian Gland/*metabolism Reptilian Proteins/*biosynthesis/genetics Snake Venoms/*biosynthesis/genetics Transcriptome/*physiology Caraiba andreae Cubophis cantherigerus; |
| Notes: | "MedlineDominguez-Perez, Dany Durban, Jordi Aguero-Chapin, Guillermin Lopez, Javier Torres Molina-Ruiz, Reinaldo Almeida, Daniela Calvete, Juan J Vasconcelos, Vitor Antunes, Agostinho eng Research Support, Non-U.S. Gov't 2018/12/07 Genomics. 2019 Dec; 111(6):1720-1727. doi: 10.1016/j.ygeno.2018.11.026. Epub 2018 Dec 1" |
