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Mol Biol Rep

Title:		Investigation of the phytochemical composition and antioxidant properties of chinar (Platanus orientalis L.) leaf infusion against ethanol-induced oxidative stress in rats
Author(s):		Dogan A; Anuk OO;
Address:		"Department of Biochemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Turkey. ahadobi@hotmail.com. Department of Biochemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, Van, Turkey"
Journal Title:		Mol Biol Rep
Year:		2019
Volume:		20190312
Issue:		3
Page Number:		3049 - 3061
DOI:		10.1007/s11033-019-04741-7
ISSN/ISBN:		1573-4978 (Electronic) 0301-4851 (Linking)
Abstract:		"Chinar (Platanus orientalis L.) is used in folk medicine against tooth and knee pain, wounds, inflammation, and stomach discomfort; however, the effects of P. orientalis leaf (PO-leaf) infusion on the liver and kidney are unknown. The aim of this study was to investigate the phytochemical composition and antioxidant properties of an infusion obtained from dried P. orientalis leaves against ethanol-induced oxidative stress (OS) in rats. After a toxicity test, thirty male Wistar rats were divided into five groups: Control, Ethanol 20%, Ethanol 20% + Silymarin (10 mg/kg), Ethanol 20% + PO-20 mg/mL infusion, and Ethanol 20% + PO-60 mg/mL infusion. The PO-leaf infusion doses were given ad libitum during 28 days to test the biochemical and antioxidant enzyme levels. According to the results, the PO-leaf contained rich compounds such as benzaldehyde, palmitic acid, 2,4-ditert-butylphenol, stearic acid, octadecanoic acid, linoleic acid, linolenic acid, kaempferol, and kaempferol derivatives. In the Ethanol group, AST, ALT, LDH, GGT, UA, and urea in the serum and GST and malondialdehyde (MDA) in the liver and erythrocyte tissues showed a significant increase compared to the Control group. AST, LDH, GGT, UA, and LDL-C levels in the serum and MDA (all tissues) significantly decreased in the Ethanol + PO-60 mg/mL group compared to the Ethanol group. SOD, GPx, and CAT activities in the kidney tissue of the Ethanol group showed a significant decrease compared to the Control group, whereas the GPx activity in kidney tissue in all of the treatment groups increased significantly compared to the Ethanol group. These findings suggest that the administration of the determined PO-leaf infusion doses might have a protective role against ethanol-induced liver and kidney damage in rats"
Keywords:		"Animals Antioxidants/*chemistry/*pharmacology Chromatography, High Pressure Liquid Ethanol/adverse effects Fatty Acids/chemistry Glutathione/metabolism Lipid Peroxidation/drug effects Male Malondialdehyde/metabolism Oxidative Stress/*drug effects Phytoche;"
Notes:		"MedlineDogan, Abdulahad Anuk, Ozgur Ozan eng TYL-2018-6774/Yuzuncu Yil Universitesi/ Netherlands 2019/03/14 Mol Biol Rep. 2019 Jun; 46(3):3049-3061. doi: 10.1007/s11033-019-04741-7. Epub 2019 Mar 12"