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Sci Adv

Title:		Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice
Author(s):		Dietschi Q; Tuberosa J; Fodoulian L; Boillat M; Kan C; Codourey J; Pauli V; Feinstein P; Carleton A; Rodriguez I;
Address:		"Department of Genetics and Evolution, Faculty of Sciences, University of Geneva, Geneva, Switzerland. Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Department of Biological Sciences, Hunter College, City University of New York and The Graduate Center Programs in Biochemistry, Biology and CUNY Neuroscience Collaborative, New York, NY, USA"
Journal Title:		Sci Adv
Year:		2022
Volume:		20221116
Issue:		46
Page Number:		eabn7450 -
DOI:		10.1126/sciadv.abn7450
ISSN/ISBN:		2375-2548 (Electronic) 2375-2548 (Linking)
Abstract:		"Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse Fpr-rs3 from its native cluster via transgenesis. Singular and specific transgenic Fpr-rs3 transcription was observed in young vomeronasal neurons but was only transient. Our study of natural and artificial dispersed gene duplications uncovers the existence of transcription-stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters and thus explains the evolutionary conserved clustered organization of functional vomeronasal genes"
Keywords:
Notes:		"PubMed-not-MEDLINEDietschi, Quentin Tuberosa, Joel Fodoulian, Leon Boillat, Madlaina Kan, Chenda Codourey, Julien Pauli, Veronique Feinstein, Paul Carleton, Alan Rodriguez, Ivan eng 2022/11/17 Sci Adv. 2022 Nov 18; 8(46):eabn7450. doi: 10.1126/sciadv.abn7450. Epub 2022 Nov 16"