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Pharm Dev Technol

Title:		Determination of the mechanism of uptake of organic vapors by chitoasn
Author(s):		Alkhamis KA; Salem MS; Khanfar MS;
Address:		"Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. khou@just.edu.jo"
Journal Title:		Pharm Dev Technol
Year:		2009
Volume:		14
Issue:		1
Page Number:		90 - 95
DOI:		10.1080/10837450802409453
ISSN/ISBN:		1097-9867 (Electronic) 1083-7450 (Linking)
Abstract:		"It was of interest to investigate the possible interactions that might occur between chitosan and various compounds of different polarities using solvent vapor sorption and Fourier Transform Infrared Spectroscopy (FTIR). The sorption system was composed of a gas inlet, a 2 meter gas cell and a gas outlet. The experimental set up allowed quantification of the free vapor and therefore the amount of the sorbed vapor by chitosan powder. The BET equation was applied to the experimental data to obtain the apparent monolayer sorption capacity (Sm) and the parameter C, which is related to the heat of interaction. Results demonstrated that the surface areas obtained for chitosan from the BET analyses for heptane, 1,4-dioxane and methanol were 421, 379 and 58 m(2)/g, respectively. These values were extremely higher than the value obtained from nitrogen vapor adsorption isotherm (4.56 m(2)/g). The difference is attributed to the partitioning of these compounds into the chitosan particles. The large difference in the Sm values between the nonpolar (heptane and 1,4-dioxane) and the semipolar compounds (methanol) also suggested that the polarity of the solvent might have a significant effect on the partitioning of the these compounds into the chitosan particles. The results obtained from this study also confirmed what was previously described regarding the ability of chitosan to act as a 'fat magnet' or a 'fat sponge'"
Keywords:		"Adsorption Algorithms Chitosan/*chemistry Dioxanes/chemistry Heptanes/chemistry Methanol/chemistry Nitrogen/chemistry Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared Technology, Pharmaceutical Temperature *Volatilization;"
Notes:		"MedlineAlkhamis, Khouloud A Salem, Mutaz S Khanfar, Mai S eng England 2008/09/30 Pharm Dev Technol. 2009; 14(1):90-5. doi: 10.1080/10837450802409453"