| Title: | Smartphone-Based Platforms for Clinical Detections in Lung-Cancer-Related Exhaled Breath Biomarkers: A Review |
| Author(s): | Yu Q; Chen J; Fu W; Muhammad KG; Li Y; Liu W; Xu L; Dong H; Wang D; Liu J; Lu Y; Chen X; |
| Address: | "Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China. School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou 310051, China. Research Center for Sensing Materials and Devices, Zhejiang Lab, Hangzhou 311100, China" |
| ISSN/ISBN: | 2079-6374 (Electronic) 2079-6374 (Linking) |
| Abstract: | "Lung cancer has been studied for decades because of its high morbidity and high mortality. Traditional methods involving bronchoscopy and needle biopsy are invasive and expensive, which makes patients suffer more risks and costs. Various noninvasive lung cancer markers, such as medical imaging indices, volatile organic compounds (VOCs), and exhaled breath condensates (EBCs), have been discovered for application in screening, diagnosis, and prognosis. However, the detection of markers still relies on bulky and professional instruments, which are limited to training personnel or laboratories. This seriously hinders population screening for early diagnosis of lung cancer. Advanced smartphones integrated with powerful applications can provide easy operation and real-time monitoring for healthcare, which demonstrates tremendous application scenarios in the biomedical analysis region from medical institutions or laboratories to personalized medicine. In this review, we propose an overview of lung-cancer-related noninvasive markers from exhaled breath, focusing on the novel development of smartphone-based platforms for the detection of these biomarkers. Lastly, we discuss the current limitations and potential solutions" |
| Keywords: | "Biomarkers Biomarkers, Tumor Breath Tests/methods Humans Lung/chemistry *Lung Neoplasms/diagnosis Smartphone *Volatile Organic Compounds/analysis exhaled breath condensate lung cancer volatile organic compounds;" |
| Notes: | "MedlineYu, Qiwen Chen, Jing Fu, Wei Muhammad, Kanhar Ghulam Li, Yi Liu, Wenxin Xu, Linxin Dong, Hao Wang, Di Liu, Jun Lu, Yanli Chen, Xing eng 82172064/National Natural Science Foundation of China/ 2020MC0AD01/Major Scientific Project of Zhejiang Lab/ LQ21F010003/Zhejiang Provincial Natural Science Foundation/ 2020M681952/China Postdoctoral Science Foundation/ 2020MC0AA04/Youth Science Fund Project of Zhejiang Lab/ 2020ZDLSF04-03/Key Research and Development Program of Shanxi/ Review Switzerland 2022/04/22 Biosensors (Basel). 2022 Apr 8; 12(4):223. doi: 10.3390/bios12040223" |
