| Title: | Real-time multi-marker measurement of organic compounds in human breath: towards fingerprinting breath |
| Author(s): | White IR; Willis KA; Whyte C; Cordell R; Blake RS; Wardlaw AJ; Rao S; Grigg J; Ellis AM; Monks PS; |
| Address: | "Department of Chemistry, University of Leicester, Leicester, UK" |
| DOI: | 10.1088/1752-7155/7/1/017112 |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients" |
| Keywords: | "Acetone/*metabolism Adolescent Adult Aged Aged, 80 and over *Breath Tests Central Nervous System Depressants/pharmacokinetics Child Cystic Fibrosis/metabolism Ethanol/pharmacokinetics Female Humans Male Mass Spectrometry/*methods Middle Aged Volatile Orga;" |
| Notes: | "MedlineWhite, Iain R Willis, Kerry A Whyte, Chris Cordell, Rebecca Blake, Robert S Wardlaw, Andrew J Rao, Satish Grigg, Jonathan Ellis, Andrew M Monks, Paul S eng England 2013/03/01 J Breath Res. 2013 Mar; 7(1):017112. doi: 10.1088/1752-7155/7/1/017112. Epub 2013 Feb 27" |
