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Metabolites

Title:		Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia
Author(s):		van Vorstenbosch R; Cheng HR; Jonkers D; Penders J; Schoon E; Masclee A; van Schooten FJ; Smolinska A; Mujagic Z;
Address:		"Department of Pharmacology and Toxicology, Maastricht University, 6227 AP Maastricht, The Netherlands. NUTRIM, School of Nutrition & Translational Research in Metabolism, Maastricht University, 6227 AP Maastricht, The Netherlands. Division of Gastroenterology-Hepatology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands. GROW, School for Oncology and Developmental Biology, Maastricht University, 6227 AP Maastricht, The Netherlands. Department of Medical Microbiology, Infectious Diseases and Infection Prevention, Maastricht University Medical Center, 6227 AP Maastricht, The Netherlands. Department of Gastroenterology and Hepatology, Catharina Hospital, 5623 EJ Eindhoven, The Netherlands"
Journal Title:		Metabolites
Year:		2022
Volume:		20221230
Issue:		1
Page Number:		-
DOI:		10.3390/metabo13010055
ISSN/ISBN:		2218-1989 (Print) 2218-1989 (Electronic) 2218-1989 (Linking)
Abstract:		"Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in several human biological matrices. This enables its non-invasive detection, but the origin of these volatile organic compounds (VOCs) and their relation to the gut microbiome are not yet fully understood. This systematic review provides an overview of the current understanding of this topic. A systematic search using PubMed, Embase, Medline, Cochrane Library, and the Web of Science according to PRISMA guidelines resulted in seventy-one included studies. In addition, a systematic search was conducted that identified five systematic reviews from which CRC-associated gut microbiota data were extracted. The included studies analyzed VOCs in feces, urine, breath, blood, tissue, and saliva. Eight studies performed microbiota analysis in addition to VOC analysis. The most frequently reported dysregulations over all matrices included short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to the tricarboxylic acid cycle and Warburg metabolism. Many of these dysregulations could be related to the shifts in CRC-associated microbiota, and thus the gut microbiota presumably contributes to the metabolic fingerprint of VOC in CRC. Future research involving VOCs analysis should include simultaneous gut microbiota analysis"
Keywords:		colorectal cancer microbiota volatile organic compounds;
Notes:		"PubMed-not-MEDLINEvan Vorstenbosch, Robert Cheng, Hao Ran Jonkers, Daisy Penders, John Schoon, Erik Masclee, Ad van Schooten, Frederik-Jan Smolinska, Agnieszka Mujagic, Zlatan eng unrestricted/PENTAX Medical Company ( )/ transscan-067, KE, no. ERA-NET TRANSSCAN/02.2018/Transscan-2, Joint Translational Call for Proposals 20216/ Review Switzerland 2023/01/22 Metabolites. 2022 Dec 30; 13(1):55. doi: 10.3390/metabo13010055"