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J Ethnopharmacol

Title:		"The processing methods, phytochemistry and pharmacology of Gastrodia elata Bl.: A comprehensive review"
Author(s):		Su Z; Yang Y; Chen S; Tang Z; Xu H;
Address:		"Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center and College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China. Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center and College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China. Electronic address: ygyang2015@sntcm.edu.cn. Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center and College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China; School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center and College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China; China Academy of Chinese Medical Sciences, Beijing, 100700, China. Shaanxi Collaborative Innovation Center of Chinese Medicine Resources Industrialization, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Innovative Drug Research Center and College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China. Electronic address: xhb2005@sntcm.edu.cn"
Journal Title:		J Ethnopharmacol
Year:		2023
Volume:		20230513
Issue:
Page Number:		116467 -
DOI:		10.1016/j.jep.2023.116467
ISSN/ISBN:		1872-7573 (Electronic) 0378-8741 (Linking)
Abstract:		"ETHNOPHARMACOLOGICAL RELEVANCE: Gastrodia elata Bl. (GE) is one of the rare Chinese medicinal materials with a long history of medicine and cooking. It consists of a variety of chemical components, including aromatic compounds, organic acids and esters, steroids, saccharides and their glycosides, etc., which has medicinal and edible value, and is widely used in various diseases, such as infantile convulsions, epilepsy, tetanus, headache, dizziness, limb numbness, rheumatism and arthralgia. It is also commonly used in health care products and cosmetics. Thus, its chemical composition and pharmacological activity have attracted more and more attention from the scientific community. AIM: In this review, the processing methods, phytochemistry and pharmacological activities of GE were comprehensively and systematically summarized, which provides a valuable reference for researchers the rational of GE. MATERIALS AND METHODS: A comprehensive search of published literature and classic books from 1958 to 2023 was conducted using online bibliographic databases PubMed, Google Scholar, ACS, Science Direct Database, CNKI and others to identify original research related to GE, its processing methods, active ingredients and pharmacological activities. RESULTS: GE is traditionally used to treat infantile convulsion, epilepsy, tetanus, headache, dizziness, limb numbness, rheumatism and arthralgia. To date, more than 435 chemical constituents were identified from GE including 276 chemical constituents, 72 volatile components and 87 synthetic compounds, which are the primary bioactive compounds. In addition, there are other biological components, such as organic acids and esters, steroids and adenosines. These extracts have nervous system and cardiovascular and cerebrovascular system activities such as sedative-hypnotic, anticonvulsant, antiepileptic, neuron protection and regeneration, analgesia, antidepressant, antihypertensive, antidiabetic, antiplatelet aggregation, anti-inflammatory, etc. CONCLUSION: This review summarizes the processing methods, chemical composition, pharmacological activities, and molecular mechanism of GE over the last 66 years, which provides a valuable reference for researchers to understand its research status and applications"
Keywords:		Humans Ethnopharmacology Phytotherapy *Gastrodia/chemistry Dizziness/drug therapy Hypesthesia/drug therapy *Tetanus/drug therapy *Epilepsy/drug therapy Anticonvulsants/pharmacology/therapeutic use Headache/drug therapy Arthralgia/drug therapy Phytochemica;
Notes:		"MedlineSu, Zenghu Yang, Yuangui Chen, Shizhong Tang, Zhishu Xu, Hongbo eng Review Ireland 2023/05/16 J Ethnopharmacol. 2023 Oct 5; 314:116467. doi: 10.1016/j.jep.2023.116467. Epub 2023 May 13"