« Previous AbstractProteolytic activity of selected commercial Lactobacillus helveticus strains on soy protein isolates    Next AbstractPlants on constant alert: elevated levels of jasmonic acid and jasmonate-induced transcripts in caterpillar-resistant maize »

Plant Signal Behav

Title:		Translocation and accumulation of nicotine via distinct spatio-temporal regulation of nicotine transporters in Nicotiana tabacum
Author(s):		Shitan N; Hayashida M; Yazaki K;
Address:		"a Department of Natural Medicinal Chemistry ; Kobe Pharmaceutical University; Motoyamakita-machi ; Kobe , Japan"
Journal Title:		Plant Signal Behav
Year:		2015
Volume:		10
Issue:		7
Page Number:		e1035852 -
DOI:		10.1080/15592324.2015.1035852
ISSN/ISBN:		1559-2324 (Electronic) 1559-2316 (Print) 1559-2316 (Linking)
Abstract:		"In plants, secondary metabolites play important roles in adaptation to the environment. Nicotine, a pyridine alkaloid in Nicotiana tabacum, functions as chemical barrier against herbivores. Nicotine produced in the root undergoes long-distance transport and accumulates mainly in the leaves. Since production of such defensive compounds is costly, plants must regulate the allocation of the products to their tissues; however, the molecular mechanism of nicotine translocation remains unclear. Our recent studies identified a novel multidrug and toxic compound extrusion (MATE)-type nicotine transporter, JAT2 (jasmonate-inducible alkaloid transporter 2). This transporter is specifically expressed in leaves, localizes to the tonoplast, and transports nicotine as its substrate. The specific induction of JAT2 expression in leaves by methyl jasmonate (MeJA) treatment suggests that this transporter plays an important role in nicotine distribution to leaves, especially under herbivore attack, by transporting nicotine into the vacuole. Considering JAT2, together with the previously identified MATE transporters JAT1, MATE1, and MATE2, and the PUP (purine permease) transporter NUP1 (nicotine uptake permease1), we show a model of nicotine translocation and accumulation via distinct spatio-temporal regulation of nicotine transporter expression. Furthermore, we discuss the possible role of nicotine transporters in determining outcrossing rates and seed production"
Keywords:		"Biological Transport Flowers/growth & development/metabolism Membrane Transport Proteins/*metabolism Models, Biological Nicotine/*metabolism Plant Proteins/*metabolism Tobacco/growth & development/*metabolism Mate MATE, multidrug and toxic compound extrus;"
Notes:		"MedlineShitan, Nobukazu Hayashida, Minaho Yazaki, Kazufumi eng Research Support, Non-U.S. Gov't 2015/08/08 Plant Signal Behav. 2015; 10(7):e1035852. doi: 10.1080/15592324.2015.1035852"