| Title: | Pilot study: volatile organic compounds as a diagnostic marker for head and neck tumors |
| Author(s): | Schmutzhard J; Rieder J; Deibl M; Schwentner IM; Schmid S; Lirk P; Abraham I; Gunkel AR; |
| Address: | "Department of Otolaryngology, Innsbruck Medical University, Innsbruck, Austria. joachim.schmutzhard@i-med.ac.at" |
| ISSN/ISBN: | 1043-3074 (Print) 1043-3074 (Linking) |
| Abstract: | "BACKGROUND: In the last decade, the analysis of volatile organic compounds (VOC) has undergone a rapid development. In this pilot study, patients with HNSCC were tested with a proton transfer reaction-mass spectrometry in order to establish a minimal invasive screening method. METHODS: Overall in a period of 2 years, 22 carcinoma patients were recruited for the study. All patients had a newly diagnosed histologically secured squamous cell carcinoma of the upper aerodigestive tract. These results were statistically compared with 3 control groups: healthy controls, high-risk, and posttherapy patients. RESULTS: Two hundred nine different masses were measured; 188 of these were evaluated. The statistical workup of the 4 study groups produced 42 different masses, which showed a statistically significant difference from the carcinoma group compared with the control groups. CONCLUSION: A screening method for HNSCC using VOC seems to be possible, but further investigation is necessary" |
| Keywords: | "Adult Biomarkers/metabolism Breath Tests/methods Carcinoma, Squamous Cell/*diagnosis/*metabolism Head and Neck Neoplasms/*diagnosis/*metabolism Humans Mass Screening/methods Mass Spectrometry Organic Chemicals/*metabolism Pilot Projects Reproducibility of;" |
| Notes: | "MedlineSchmutzhard, Joachim Rieder, Josef Deibl, Martina Schwentner, Ilona M Schmid, Stefan Lirk, Philip Abraham, Irene Gunkel, Andreas R eng Controlled Clinical Trial 2008/02/21 Head Neck. 2008 Jun; 30(6):743-9. doi: 10.1002/hed.20779" |
