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Nat Prod Res

Title:		A quinoline alkaloid rich Quisqualis indica floral extract enhances the bioactivity
Author(s):		Rout PK; Kumar P; Rao YR; Kumar A; Bawankule DU; Singh R; Singh KB; Chanotiya CS; Naik SN;
Address:		"Chemical Sciences Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India. Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Forest and Marine Products Department, CSIR-Regional Research Laboratory (IMMT), Bhubaneswar, Odisha, India. Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India. Center for Rural Development and Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India"
Journal Title:		Nat Prod Res
Year:		2021
Volume:		20190702
Issue:		10
Page Number:		1632 - 1638
DOI:		10.1080/14786419.2019.1634709
ISSN/ISBN:		1478-6427 (Electronic) 1478-6419 (Linking)
Abstract:		"A volatile alkaloid quinoline-4-carbonitrile (QCN) was isolated from the floral extract of Quisqualis indica. Major compounds were trans-linalool oxide (1.0, 4.5%), methyl benzoate (1.0, 4.0%), 2,2,6-trimethyl-6-vinyl-tetrahydropyran-3-one (7.4, 17.8%), 2,2,6-trimethyl-6-vinyl-tetrahydropyran-3-ol (1.0, 1.2%), (E,E)-alpha-farnesene (29.1, 16.1%), QCN (5.7, 1.3%) in live and picked flowers, respectively. Flower compositions were altered due to change in enzymatic reaction at the time of picking. Some rearrangements of oxygenated terpenoids occurred in the process of hydrodistillation to obtain essential oil. Chemical synthesis of QCN and its selectively reduced products derived from QCN were prepared through green reaction process. The catalytic modification of QCN has produced quinoline-4-methylamine; the later compound has shown enhanced bio-activities. QCN and floral extract (absolute) have shown potential anti-inflammatory and antioxidant activities. Besides, floral absolute has shown significant anti-inflammatory and antioxidant activities due to improved QCN (19.7%) content to synergize amongst terpenoids and benzenoids as compared to the essential oil with 1.1% of QCN"
Keywords:		Alkaloids/analysis/*pharmacology Anti-Inflammatory Agents/pharmacology Antioxidants/analysis/pharmacology Carbon-13 Magnetic Resonance Spectroscopy Combretaceae/*chemistry Flowers/*chemistry Plant Extracts/chemistry/*pharmacology Proton Magnetic Resonance;
Notes:		"MedlineRout, Prasant Kumar Kumar, Prashant Rao, Y Ramachandra Kumar, Anant Bawankule, Dnyaneshwar U Singh, Ruchi Singh, Kijay Bahadur Chanotiya, Chandan Singh Naik, S N eng England 2019/07/03 Nat Prod Res. 2021 May; 35(10):1632-1638. doi: 10.1080/14786419.2019.1634709. Epub 2019 Jul 2"